A simple evaluation of the benefit of combined kinetic analysis of multiple injection dynamic PET scans

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dc.contributor.authorGu, Fengyun
dc.contributor.authorO'Sullivan, Finbarr
dc.contributor.authorMuzi, Mark
dc.contributor.authorMankoff, David A.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderNational Institutes of Healthen
dc.date.accessioned2020-09-24T11:55:54Z
dc.date.available2020-09-24T11:55:54Z
dc.date.issued2019-11
dc.date.updated2020-09-24T10:56:39Z
dc.description.abstractThe multiple injection dynamic Positron Emission Tomography (PET) scanning is used in the clinical management of certain groups of cancer patients and in medical research. The analysis of such studies can be approached in one of two ways: analyze individual injections separately to recover tracer kinetic information, or concatenate data from separate injections and carry out a combined analysis. Separate analysis offers some simplicity but may not be as efficient statistically. The mixture technique is readily implemented in a separated or combined analysis mode. We evaluate these approaches in a 1-D simulation setting matched to the mathematical complexity of PET. These simulations are largely guided by experience with breast cancer flow-metabolism mismatch studies using 15O-Water (H2O) and 18F-Fluorodeoxyglucose (FDG). An efficient implementation in the R (an open-source environment) is used to implement simulations. The simulations evaluate mean square error (MSE) characteristics, for separate and combined analysis, both as a function of dose. The relationship between MSE characteristics of the underlying source distribution is described and the combined analysis is found to reduce MSE by between 18.1% and 33.85%. The quantitative advantages of combined approach have been demonstrated.en
dc.description.sponsorshipScience Foundation Ireland (Grant No. PI-11/1027); National Institutes of Health (National Cancer Institute USA (grant R33-CA225310 and NIH/NCI R50-CA211270))en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGu, F., O’Sullivan, F., Muzi, M. and Mankoff, D. A. 'A Simple Evaluation of the Benefit of Combined Kinetic Analysis of Multiple Injection Dynamic PET Scans'. 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Manchester, UK, 26 Oct.-2 Nov. 2019, 1-3. doi: 10.1109/NSS/MIC42101.2019.9060073en
dc.identifier.doi10.1109/NSS/MIC42101.2019.9060073en
dc.identifier.endpage3en
dc.identifier.isbn978-1-7281-4164-0
dc.identifier.isbn978-1-7281-4165-7
dc.identifier.issn2577-0829
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/10582
dc.language.isoenen
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.relation.urihttps://ieeexplore.ieee.org/document/9060073
dc.rights© 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.en
dc.subjectCanceren
dc.subjectImage reconstructionen
dc.subjectMean square error methodsen
dc.subjectMedical image processingen
dc.subjectPositron emission tomographyen
dc.subjectSeparated combined analysisen
dc.subject1D simulationen
dc.subjectCombined kinetic analysisen
dc.subjectCancer patientsen
dc.subjectTracer kinetic informationen
dc.subjectInjection dynamic positron emission tomography scanningen
dc.subjectInjection dynamic PET scansen
dc.subjectBreast cancer flow-metabolism mismatchen
dc.subject18F-fluorodeoxyglucoseen
dc.subject15O-wateren
dc.subjectMean square error characteristicsen
dc.subjectTumorsen
dc.subjectAnalytical modelsen
dc.subjectMixture modelsen
dc.subjectKinetic theoryen
dc.subjectBreast canceren
dc.subjectMultiple Injectionsen
dc.subjectCombined Kinetic Modellingen
dc.subjectSimulationen
dc.subjectMixture analysisen
dc.titleA simple evaluation of the benefit of combined kinetic analysis of multiple injection dynamic PET scansen
dc.typeConference itemen
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