Diffusible Signal Factor (DSF)-dependent quorum sensing in pathogenic bacteria and its exploitation for disease control

dc.check.date2017-09-29
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorDow, J. Maxwell
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2016-10-20T08:13:52Z
dc.date.available2016-10-20T08:13:52Z
dc.date.issued2016-09-29
dc.description.abstractCell-to-cell signals of the Diffusible Signal Factor (DSF) family are cis-2-unsaturated fatty acids of differing chain length and branching pattern. DSF signalling has been described in diverse bacteria to include plant and human pathogens where it acts to regulate functions such as biofilm formation, antibiotic tolerance and the production of virulence factors. DSF family signals can also participate in interspecies signalling with other bacteria and interkingdom signaling such as with the yeast Candida albicans. Interference with DSF signalling may afford new opportunities for the control of bacterial disease. Such strategies will depend in part on detailed knowledge of the molecular mechanisms underlying the processes of signal synthesis, perception and turnover. Here, I review both recent progress in understanding DSF signalling at the molecular level and prospects for translating this knowledge into approaches for disease control.en
dc.description.sponsorshipScience Foundation Ireland (SFI 07/IN.1/B955; SFI 07/IN.1/B955/IRPs; SFI 11/TIDA/B2036)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDow, J. M. (2016) 'Diffusible Signal Factor (DSF)-dependent quorum sensing in pathogenic bacteria and its exploitation for disease control', Journal of Applied Microbiology, 122(1), pp. 2-11. doi:10.1111/jam.13307en
dc.identifier.doi10.1111/jam.13307
dc.identifier.endpage11
dc.identifier.issn1364-5072
dc.identifier.issued1
dc.identifier.journaltitleJournal of Applied Microbiologyen
dc.identifier.startpage2
dc.identifier.urihttps://hdl.handle.net/10468/3193
dc.identifier.volume122
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.rights© 2016, John Wiley & Sons, Inc. This is the peer reviewed version of the following article: Dow, J. M. (2016) 'Diffusible Signal Factor (DSF)-dependent quorum sensing in pathogenic bacteria and its exploitation for disease control', Journal of Applied Microbiology, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/jam.13307/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en
dc.subjectVirulenceen
dc.subjectSignallingen
dc.subjectPlant pathologyen
dc.subjectPseudomonadsen
dc.subjectMicrobial physiologyen
dc.titleDiffusible Signal Factor (DSF)-dependent quorum sensing in pathogenic bacteria and its exploitation for disease controlen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
1412.pdf
Size:
340.79 KB
Format:
Adobe Portable Document Format
Description:
Accepted Version
License bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description: