The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes

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dc.contributor.authorReen, F. Jerry
dc.contributor.authorMcGlacken, Gerard P.
dc.contributor.authorO'Gara, Fergal
dc.contributor.funderEnterprise Irelanden
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderHorizon 2020en
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.contributor.funderIrish Research Council for Science, Engineering and Technologyen
dc.contributor.funderHealth Research Boarden
dc.contributor.funderIrish Thoracic Society
dc.date.accessioned2018-04-05T08:48:36Z
dc.date.available2018-04-05T08:48:36Z
dc.date.issued2018-03-26
dc.date.updated2018-04-03T09:19:50Z
dc.description.abstractPopulation dynamics within natural ecosystems is underpinned by microbial diversity and the heterogeneity of host-microbe and microbe-microbe interactions. Small molecule signals that intersperse between species have been shown to govern many virulence-related processes in established and emerging pathogens. Understanding the capacity of microbes to decode diverse languages and adapt to the presence of ‘non-self’ cells, will provide an important new direction to the understanding of the ‘polycellular’ interactome. Alkyl Quinolones (AQs) have been described in the ESKAPE pathogen Pseudomonas aeruginosa, the primary agent associated with mortality in patients with Cystic Fibrosis and the third most prevalent nosocomial pathogen worldwide. The role of these molecules in governing the physiology and virulence of P. aeruginosa and other pathogens has received considerable attention, while a role in interspecies and interkingdom communication has recently emerged. Herein we discuss recent advances in our understanding of AQ signalling and communication in the context of microbe-microbe and microbe-host interactions. The integrated knowledge from these systems-based investigations will facilitate the development of new therapeutics based on the AQ framework that serve to disarm the pathogenesis of P. aeruginosa and competing pathogens.en
dc.description.sponsorshipEnterprise Ireland (CF-2017-0757-P); Department of Agriculture, Food and the Marine (FIRM 1/F009/MabS; FIRM13/F/516); Irish Research Council for Science, Engineering and Technology (GOIPG/2014/647); Health Research Board/Irish Thoracic Society (MRCG-2014-6)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationReen, F. J., McGlacken, G. P. and O'Gara, F. (2018) 'The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes', FEMS Microbiology Letters. doi:10.1093/femsle/fny076en
dc.identifier.doi10.1093/femsle/fny076
dc.identifier.issn0378-1097
dc.identifier.issn1574-6968
dc.identifier.journaltitleFEMS Microbiology Lettersen
dc.identifier.urihttps://hdl.handle.net/10468/5735
dc.language.isoenen
dc.publisherOxford University Press on behalf of Federation of European Microbiological Societiesen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/607786/EU/BluePharmTrain/BLUEPHARMTRAINen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/312184/EU/Increasing Value and Flow in the Marine Biodiscovery Pipeline/PHARMASEAen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/311975/EU/Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications/MACUMBAen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/287589/EU/Marine Microbial Biodiversity, Bioinformatics and Biotechnology/MICRO B3en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::IA/634486/EU/Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea/INMAREen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/13/TIDA/B2625/IE/Small molecule inhibitors of HIF-1: a new class of anti-cancer therapeutics./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2411/IE/Development of small molecule therapeutics for medical intervention: anti-biofilm inhibitors for the medical device sector./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2405/IE/Optimised detection of key biomarkers of Pseudomonas aeruginosa towards a clinical application/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/14/TIDA/2438/IE/Next Generation Antibiotics: anti-biofilm, anti-pathogenic natural bioactives from marine microorganisms./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/15/TIDA/2977/IE/Pre-clinical testing of novel fungal biofilm blockers for the medical device sector./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Investigator Programme/12/IP/1315/IE/The Direct Arylation of Pyrones, Coumarins, Pyridones and Quinolones/en
dc.rights© 2018, Federation of European Microbiological Societies. Published by Oxford University Press. All rights reserved. This is a pre-copyedited, author-produced PDF of an article accepted for publication in FEMS Microbiology Letters following peer review. The version of record, Reen, F. J., McGlacken, G. P. and O'Gara, F. (2018) 'The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes', is available online at: https://doi.org/10.1093/femsle/fny076en
dc.subjectPseudomonas aeruginosaen
dc.subjectPseudomonas Quinolone Signalen
dc.subjectPQSen
dc.subjectAlkylquinolonesen
dc.subjectAnti-infectivesen
dc.subjectInterspecies signallingen
dc.subjectQuorum sensingen
dc.titleThe expanding horizon of alkyl quinolone signalling and communication in polycellular interactomesen
dc.typeReviewen
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