Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson's disease.

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dc.contributor.authorCollins, Louise M.
dc.contributor.authorGavin, Aisling M.
dc.contributor.authorWalsh, Sinéad
dc.contributor.authorSullivan, Aideen M.
dc.contributor.authorWyatt, Sean L.
dc.contributor.authorO'Keeffe, Gerard W.
dc.contributor.authorNolan, Yvonne M.
dc.contributor.authorToulouse, André
dc.contributor.funderHealth Research Boarden
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderCollege of Medicine and Health, University College Cork
dc.date.accessioned2014-08-12T13:57:22Z
dc.date.available2014-08-12T13:57:22Z
dc.date.issued2014-05
dc.date.updated2014-05-14T13:30:10Z
dc.description.abstractWe have previously demonstrated that mitogen-activated protein kinase phosphatase 1, Mkp1, is expressed in the developing and rat adult substantia nigra and striatum, where it promotes the growth of nigral dopaminergic neurons. Mkp1 may therefore have therapeutic potential for Parkinson's disease. In the present study, we have assessed the expression of Mkp1 and TH in the substantia nigra and striatum of parkinsonian rat models. Expression was measured at 4 and 10 days post-lesion in the 6-hydroxydopamine (6-OHDA) medial forebrain bundle lesion model and after 4, 10 and 28 days in the 6-OHDA striatal lesion model. Our results show that Mkp1 expression was transiently up-regulated in the substantia nigra at 4 days post-6-OHDA administration in the two models while TH expression was decreased at the later time-points examined. These data suggest that Mkp1 may play a role in counteracting the neurotoxic effects of 6-OHDA in nigral dopaminergic neurons.en
dc.description.sponsorshipHealth Research Board (HRA/2009/127); Science Foundation Ireland (Grant No. SFI/RFP/NSC1298) (10/RFP/NES5786)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCOLLINS, L. M., GAVIN, A. M., WALSH, S., SULLIVAN, A. M., WYATT, S. L., O'KEEFFE, G. W., NOLAN, Y. M. & TOULOUSE, A. 2014. Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson's disease. SpringerPlus, 3, 205. doi: 10.1186/2193-1801-3-205en
dc.identifier.doi10.1186/2193-1801-3-205
dc.identifier.endpage205en
dc.identifier.issued1en
dc.identifier.journaltitleSpringerPlusen
dc.identifier.startpage205en
dc.identifier.urihttps://hdl.handle.net/10468/1616
dc.identifier.volume3en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urihttp://www.springerplus.com/content/3/1/205
dc.rights© 2014 Collins et al.; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly crediteden
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en
dc.subjectParkinson’s diseaseen
dc.subject6-hydroxydopamineen
dc.subjectMAP kinase phosphatase 1 (Mkp1)en
dc.titleExpression of endogenous Mkp1 in 6-OHDA rat models of Parkinson's disease.en
dc.typeArticle (peer-reviewed)en
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