Developing spore-forming gut bacteria as model organisms

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dc.contributor.authorFaherty-McGrath, Louisa B.
dc.contributor.authorvan Sinderen, D.
dc.contributor.authorBrowne, H.P.
dc.contributor.funderResearch Ireland, 12/RC/2273-16/SP/3827
dc.contributor.funderEuropean Research Council, ERC, SYNergize 101115994
dc.date.accessioned2026-05-15T13:50:01Z
dc.date.available2026-05-15T13:50:01Z
dc.date.issued2026-08
dc.description.abstractAnaerobic gut bacteria have highly evolved functions that promote transmission between human hosts. These include resilient spores produced by many Bacillota (formerly Firmicutes) bacteria, which are tolerant to extended ambient oxygen exposure. Recent culturing and genomic studies have revealed the taxonomic diversity of gut spore-formers and their prevalence in human populations. However, due to a reliance on spore-forming model organisms that are not representative of commensal gut bacteria, we still have a limited understanding of gut microbiome-specific sporulation processes and their underlying genetics. In this opinion article, we outline a rational path for development of new model organisms derived from commensal spore-forming gut bacteria in order to obtain fundamental insights into sporulation and to provide a discovery platform for novel probiotic or microbiome-based therapeutic development.en
dc.description.sponsorshipWe acknowledge funding support from Science Foundation Ireland (SFI
dc.description.sponsorshipnow Research Ireland) under grant no. 12/RC/2273 and 16/SP/3827 . H.P.B. is funded by the European Research Council starter grant: SYNergize 101115994 .
dc.description.versionPublished Version
dc.format.extent11
dc.format.mimetypeapplication/pdfen
dc.identifier.authororcidFaherty-McGrath, Louisa B.
dc.identifier.authororcidvan Sinderen, D.§0000-0003-1823-7957
dc.identifier.authororcidBrowne, H.P.
dc.identifier.citationFaherty-McGrath, L B, van Sinderen, D & Browne, H P 2026, 'Developing spore-forming gut bacteria as model organisms', Trends in Microbiology, vol. 34, no. 8, pp. 840-850. https://doi.org/10.1016/j.tim.2026.04.006
dc.identifier.doi10.1016/j.tim.2026.04.006
dc.identifier.endpage850
dc.identifier.issn0966-842X
dc.identifier.issued8
dc.identifier.journaltitleTrends in Microbiology
dc.identifier.otherRIS: urn:48EFE266C503E7CBA31A840A417757EB
dc.identifier.otherORCID: /0000-0003-1823-7957/work/217137294
dc.identifier.startpage840
dc.identifier.urihttps://hdl.handle.net/10468/18772
dc.identifier.volume34
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.urihttps://www.scopus.com/pages/publications/105037771671
dc.relation.urihttps://www.scopus.com/pages/publications/105037771671?origin=resultslist
dc.rights© 2026, The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.statusPeer reviewed
dc.subjectBacillota
dc.subjectBacterial spore
dc.subjectCommensal
dc.subjectGut microbiome
dc.subjectHuman
dc.subjectIntestine
dc.subjectIntestine flora
dc.subjectMicrobiome
dc.subjectModel organisms
dc.subjectNonhuman
dc.subjectOxygen
dc.subjectPrevalence
dc.subjectProbiotic agent
dc.subjectProbiotics
dc.subjectReview
dc.subjectSpore-forming gut bacteria
dc.subjectSporogenesis
dc.subject[APCMicrobiome]
dc.subject[Microbiology]
dc.subjectspecies diversity
dc.subjectgut microbiome
dc.subjectmodel organisms
dc.subjectspore-forming gut bacteria
dc.subjectprobiotics
dc.titleDeveloping spore-forming gut bacteria as model organismsen
dc.typeArticle (peer-reviewed)
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