Novel preparations of glucagon for the prevention and treatment of hypoglycemia

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dc.contributor.authorHawkes, Colin P.
dc.contributor.authorDe Leon, D. D.
dc.contributor.authorRickels, M. R.
dc.contributor.funderU.S. Public Health Serviceen
dc.date.accessioned2022-01-27T10:52:17Z
dc.date.available2022-01-27T10:52:17Z
dc.date.issued2019
dc.description.abstractPurpose of Review: New more stable formulations of glucagon have recently become available, and these provide an opportunity to expand the clinical roles of this hormone in the prevention and management of insulin-induced hypoglycemia. This is applicable in type 1 diabetes, hyperinsulinism, and alimentary hypoglycemia. The aim of this review is to describe these new formulations of glucagon and to provide an overview of current and future therapeutic opportunities that these may provide. Recent Findings: Four main categories of glucagon formulation have been studied: intranasal glucagon, biochaperone glucagon, dasiglucagon, and non-aqueous soluble glucagon. All four have demonstrated similar glycemic responses to standard glucagon formulations when administered during hypoglycemia. In addition, potential roles of these formulations in the management of congenital hyperinsulinism, alimentary hypoglycemia, and exercise-induced hypoglycemia in type 1 diabetes have been described. Summary: As our experience with newer glucagon preparations increases, the role of glucagon is likely to expand beyond the emergency use that this medication has been limited to in the past. The innovations described in this review likely represent early examples of a pending large repertoire of indications for stable glucagon. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.en
dc.description.sponsorshipU.S. Public Health Service (Grants R01 DK091331; R01 DK056268; R01 DK098517)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHawkes, C. P., De Leon, D. D. and Rickels, M. R. (2019) ‘Novel preparations of glucagon for the prevention and treatment of hypoglycemia’, Current Diabetes Reports, 19(10), pp.1-10. doi: 10.1007/s11892-019-1216-4en
dc.identifier.doi10.1007/s11892-019-1216-4
dc.identifier.endpage10
dc.identifier.issn1534-4827
dc.identifier.issued10
dc.identifier.journaltitleCurrent Diabetes Reportsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/12485
dc.language.isoenen
dc.publisherSpringeren
dc.rights© 2019, Springer Science+Business Media, LLC, part of Springer Nature. This is a post-peer-review, pre-copyedit version of an article published in Current Diabetes Reports. The final authenticated version is available online at: https://doi.org/10.1007/s11892-019-1216-4en
dc.subjectAlimentaryen
dc.subjectDiabetesen
dc.subjectFormulationen
dc.subjectGlucagonen
dc.subjectHyperinsulinismen
dc.subjectHypoglycemiaen
dc.titleNovel preparations of glucagon for the prevention and treatment of hypoglycemiaen
dc.typeArticle (peer-reviewed)en
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