Macrotroponin as a cause of falsely elevated cardiac troponin in systemic sclerosis

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dc.contributor.authorTio, Sherdyaen
dc.contributor.authorZia, Fatimaen
dc.contributor.authorJoyce, Caroline Marthaen
dc.contributor.authorHalsall, David J.en
dc.contributor.authorRyan, Johnen
dc.date.accessioned2025-09-22T14:10:18Z
dc.date.available2025-09-22T14:10:18Z
dc.date.issued2025-09-17en
dc.description.abstractThis case report discusses a patient in his late 30s with recent diagnosis of systemic sclerosis (SSc) who presented with persistently elevated cardiac troponin (cTn) levels, raising concerns for cardiac involvement. Despite elevated troponin-I (cTnI) and troponin-T (cTnT), clinical investigations, including echocardiogram and cardiac MRI, were unremarkable. The persistence of elevated troponin without corresponding clinical evidence prompted further investigation, leading to the identification of macrotroponin as the cause. This case emphasizes the importance of recognising macrotroponin as an interferent in patients with unexplained raised troponin levels to avoid unnecessary cardiac interventions. Acknowledgements for their contribution in patient care and clinical insights relevant to the case: Professor Gráinne Murphy and Professor Sinead Harney, Consultant Rheumatologist, Cork University Hospital Dr Ronan Curtin, Consultant Cardiologist, Cork University Hospitalen
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide266536en
dc.identifier.citationTio, S., Zia, F., Joyce, C.M., Halsall, D.J. and Ryan, J. (2025) 'Macrotroponin as a cause of falsely elevated cardiac troponin in systemic sclerosis', BMJ Case Reports, 18(9), e266536 (7pp). https://doi.org/10.1136/bcr-2025-266536en
dc.identifier.doi10.1136/bcr-2025-266536en
dc.identifier.endpage7en
dc.identifier.issued9en
dc.identifier.journaltitleBMJ Case Reportsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/17890
dc.identifier.volume18en
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.relation.urihttps://casereports.bmj.com/content/18/9/e266536en
dc.rights© 2025, BMJ Publishing Group Ltd. This article has been accepted for publication in BMJ Case Reports 2025, following peer review, and the Version of Record can be accessed online at: https://doi.org/10.1136/bcr-2025-266536. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where a another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC-BY-NC 4.0) http://creativecommons.orgen
dc.rights.urittps://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectSystemic sclerosisen
dc.subjectSScen
dc.subjectElevated cardiac troponinen
dc.subjectcTnen
dc.titleMacrotroponin as a cause of falsely elevated cardiac troponin in systemic sclerosisen
dc.typeArticle (peer-reviewed)en
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