Expressional changes in stemness markers post electrochemotherapy in pancreatic cancer cells

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dc.check.date2020-03-15
dc.check.infoAccess to this article is restricted until 24 months after publication by request of the publisher.en
dc.contributor.authorAli, Shahzad
dc.contributor.authorGill, Kheshwant S.
dc.contributor.authorSaglio, Giuseppe
dc.contributor.authorCilloni, Daniela
dc.contributor.authorSoden, Declan M.
dc.contributor.authorForde, Patrick F.
dc.contributor.funderBreakthrough Cancer Research, Ireland
dc.contributor.funderCork Cancer Research Centre, College of Medicine and Health, University College Cork
dc.contributor.funderTeddy Daly Memorial Fund, Ireland
dc.date.accessioned2018-03-26T11:47:14Z
dc.date.available2018-03-26T11:47:14Z
dc.date.issued2018-03-15
dc.date.updated2018-03-21T11:43:34Z
dc.description.abstractPancreatic cancer is one of the most lethal cancers with high metastatic potential and strong chemoresistance. The capability of a tumor to grow and propagate is dependent on a small subset of cells within a tumor, termed cancer stem cells. Cancer stem cells exhibit great tumorigenicity and are closely correlated with drug resistance and tumor recurrence. The aim of our study was to illustrate electrochemotherapy as an effective treatment for pancreatic cancer along with the expression change in stemness genes (Nanog, Sox2 and Oct3/4) in pancreatic cancer cells post electrochemotherapy with bleomycin, cisplatin and oxaliplatin. Our results showed the enhanced expression of Nanog and decreased expression level of Oct3/4 after electrochemotherpy. We thus propose that these stemness markerS may have important roles in the initiation and/or recurrence of pancreatic cancer, and consequently may serve as important molecular diagnostics and/or therapeutic targets for the development of novel treatment strategies in pancreatic cancer patients. In conclusion, targeting these stemness factors could potentially improve electrochemotherapy as a treatment and preventing recurrence.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAli, S., Gill, K. S., Saglio. G., Cilloni, D., Soden, D. M. and Forde, P. F. (2018) 'Expressional changes in stemness markers post electrochemotherapy in pancreatic cancer cells', Bioelectrochemistry. doi:10.1016/j.bioelechem.2018.03.009en
dc.identifier.doi10.1016/j.bioelechem.2018.03.009
dc.identifier.issn1567-5394
dc.identifier.issn1878-562X
dc.identifier.journaltitleBioelectrochemistryen
dc.identifier.urihttps://hdl.handle.net/10468/5693
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.rights© 2018, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectPancreaticen
dc.subjectStemnessen
dc.subjectRecurrenceen
dc.subjectElectrochemotherapyen
dc.titleExpressional changes in stemness markers post electrochemotherapy in pancreatic cancer cellsen
dc.typeArticle (peer-reviewed)en
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