The DSF family of cell-cell signals: an expanding class of bacterial virulence regulators

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dc.contributor.authorRyan, Robert P.
dc.contributor.authorAn, Shi-Qi
dc.contributor.authorAllan, John H.
dc.contributor.authorMcCarthy, Yvonne
dc.contributor.authorDow, J. Maxwell
dc.contributor.funderWellcome Trust, United Kingdom
dc.contributor.funderEuropean Commission
dc.date.accessioned2016-02-17T10:07:57Z
dc.date.available2016-02-17T10:07:57Z
dc.date.issued2015
dc.description.abstractMany pathogenic bacteria use cell-cell signaling systems involving the synthesis and perception of diffusible signal molecules to control virulence as a response to cell density or confinement to niches. Bacteria produce signals of diverse structural classes. Signal molecules of the diffusible signal factor (DSF) family are cis-2-unsaturated fatty acids. The paradigm is cis-11-methyl-2-dodecenoic acid from Xanthomonas campestris pv. campestris (Xcc), which controls virulence in this plant pathogen. Although DSF synthesis was thought to be restricted to the xanthomonads, it is now known that structurally related molecules are produced by the unrelated bacteria Burkholderia cenocepacia and Pseudomonas aeruginosa. Furthermore, signaling involving these DSF family members contributes to bacterial virulence, formation of biofilms and antibiotic tolerance in these important human pathogens. Here we review the recent advances in understanding DSF signaling and its regulatory role in different bacteria. These advances include the description of the pathway/mechanism of DSF biosynthesis, identification of novel DSF synthases and new members of the DSF family, the demonstration of a diversity of DSF sensors to include proteins with a Per-Arnt-Sim (PAS) domain and the description of some of the signal transduction mechanisms that impinge on virulence factor expression. In addition, we address the role of DSF family signals in interspecies signaling that modulates the behavior of other microorganisms. Finally, we consider a number of recently reported approaches for the control of bacterial virulence through the modulation of DSF signaling.en
dc.description.sponsorshipWellcome Trust, United Kingdom (Senior Fellowship Grant WT100204AIA); European Commission (Seventh Framework Programme Grant No. 603038)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide1004986
dc.identifier.citationRyan RP, An S-q, Allan JH, McCarthy Y, Dow JM (2015) The DSF Family of Cell–Cell Signals: An Expanding Class of Bacterial Virulence Regulators. PLoS Pathog 11(7): e1004986. doi:10.1371/journal.ppat.1004986
dc.identifier.doi10.1371/journal.ppat.1004986
dc.identifier.issn1553-7366
dc.identifier.issued7en
dc.identifier.journaltitlePLOS PATHOGENSen
dc.identifier.urihttps://hdl.handle.net/10468/2304
dc.identifier.volume11en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rights© 2015 Ryan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectQuorum sensing signalen
dc.subjectOryzae pv. oryzicolaen
dc.subjectCyclic di-GMPen
dc.subjectGyp domain proteinen
dc.subjectCitri subsp citrien
dc.subjectXanthomonas campestrisen
dc.subjectXylella fastidiosaen
dc.subjectStenotrophomonas maltophiliaen
dc.subjectBurkholderia cenocepaciaen
dc.subjectPseudomonas aeruginosaen
dc.titleThe DSF family of cell-cell signals: an expanding class of bacterial virulence regulatorsen
dc.typeArticle (peer-reviewed)en
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