Ethanolamine: A potential promoiety with additional effects in the brain [Mini review]

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dc.contributor.authorGwanyanya, Asfree
dc.contributor.authorGodsmark, Christie Nicole
dc.contributor.authorKelly-Laubscher, Roisin
dc.date.accessioned2022-08-05T11:08:39Z
dc.date.available2022-08-05T11:08:39Z
dc.date.issued2020-12-11
dc.date.updated2022-08-05T11:00:21Z
dc.description.abstractEthanolamine is a bioactive molecule found in several cells, including those in the central nervous system (CNS). In the brain, ethanolamine and ethanolamine-related molecules have emerged as prodrug moieties that can promote drug movement across the blood-brain barrier. This improvement in the ability to target drugs to the brain may also mean that in the process ethanolamine concentrations in the brain are increased enough for ethanolamine to exert its own neurological ac-tions. Ethanolamine and its associated products have various positive functions ranging from cell signaling to molecular storage, and alterations in their levels have been linked to neurodegenerative conditions such as Alzheimer's disease. This mini-review focuses on the effects of ethanolamine in the CNS and highlights the possible implications of these effects for drug design.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGwanyanya, A., Godsmark, C. N. and Kelly-Laubscher, R. (2022) 'Ethanolamine: A Potential Promoiety with Additional Effects in the Brain. [Mini review]', CNS & Neurological Disorders Drug Targets, 21 (2), pp. 108-117. doi: 10.2174/1871527319999201211204645en
dc.identifier.doi10.2174/1871527319999201211204645en
dc.identifier.endpage117en
dc.identifier.issn1996-3181
dc.identifier.issued2en
dc.identifier.journaltitleCNS & neurological disorders drug targetsen
dc.identifier.startpage108en
dc.identifier.urihttps://hdl.handle.net/10468/13455
dc.identifier.volume21en
dc.language.isoenen
dc.publisherBentham Scienceen
dc.relation.urihttps://doi.org/10.2174/1871527319999201211204645
dc.rightsThis is the accepted version of an article published in CNS & Neurological Disorders - Drug Targets. The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/10.2174/1871527319999201211204645en
dc.subjectEthanolamineen
dc.subjectBrainen
dc.subjectCNSen
dc.subjectPhospholipidsen
dc.subjectProdrugen
dc.subjectSynapticen
dc.subjectNeuromodulatoren
dc.titleEthanolamine: A potential promoiety with additional effects in the brain [Mini review]en
dc.typeArticle (peer-reviewed)en
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