Obstetric mode of delivery and child psychological development

Curran, Eileen A.

Obstetric mode of delivery and child psychological development

dc.check.chapterOfThesis	6
dc.check.embargoformat	Both hard copy thesis and e-thesis	en
dc.check.opt-out	Not applicable	en
dc.check.reason	This thesis is due for publication or the author is actively seeking to publish this material	en
dc.contributor.advisor	Khashan, Ali	en
dc.contributor.advisor	Kearney, Patricia M.	en
dc.contributor.advisor	Kenny, Louise C.	en
dc.contributor.advisor	Cryan, John F.	en
dc.contributor.advisor	Dinan, Timothy G.	en
dc.contributor.author	Curran, Eileen A.
dc.contributor.funder	Science Foundation Ireland	en
dc.contributor.funder	Irish Centre for Fetal and Neonatal Translational Research (INFANT)	en
dc.date.accessioned	2016-06-01T08:56:20Z
dc.date.issued	2016
dc.date.submitted	2016
dc.description.abstract	Background/aims: Objective of the current thesis is to investigate the potential impact of birth by Caesarean section (CS) on child psychological development, including autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), behavioural difficulties and school performance. Structure/methods: Published literature to date on birth by CS, ASD and ADHD was reviewed (Chapter 2). Data from the UK Millennium Cohort Study (MCS) were analysed to determine the association between CS and ASD, ADHD and parent-reported behavioural difficulties (Chapter 3). The Swedish National Registers were used to further assess the association with ASD, ADHD and school performance (Chapters 4-6). Results: In the review, children born by CS were 23% more likely to be diagnosed with ASD after controlling for potential confounders. Only two studies reported adjusted estimates on the association between birth by CS and ADHD, results were conflicting and limited. CS was not associated with ASD, ADHD or behavioural difficulties in the UK MCS. In the Swedish National Registers, children born by CS were more likely to be diagnosed with ASD or ADHD. The association with elective CS did not persist when compared amongst siblings. There was little evidence of an association between birth by elective CS and poor school performance. Children born by elective CS had slight reduction in school performance. Conclusions: The lack of association with the elective CS in the sibling design studies indicates that the association in the population is most probably due to confounding. A small but significant association was found between birth by CS and school performance. However, the effect may have been due to residual confounding or confounding by indication and should be interpreted with caution. The overall conclusion is that birth by CS does not appear to have a causal relationship with the aspects of child psychological development investigated.	en
dc.description.status	Not peer reviewed	en
dc.description.version	Accepted Version
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Curran, E. A. 2016. Obstetric mode of delivery and child psychological development. PhD Thesis, University College Cork.	en
dc.identifier.endpage	265	en
dc.identifier.uri	https://hdl.handle.net/10468/2659
dc.language.iso	en	en
dc.publisher	University College Cork	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.rights	© 2016, Eileen A. Curran.	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	en
dc.subject	Autistic spectrum disorder	en
dc.subject	Attention-deficit/hyperactivity disorder	en
dc.subject	School performance	en
dc.subject	Caesarean section	en
dc.subject	Mode of delivery	en
dc.subject	Child behaviour	en
dc.thesis.opt-out	false
dc.title	Obstetric mode of delivery and child psychological development	en
dc.type	Doctoral thesis	en
dc.type.qualificationlevel	Doctoral Degree (Structured)	en
dc.type.qualificationname	PhD (Medicine and Health)	en
ucc.workflow.supervisor	a.khashan@ucc.ie