Protective lifestyle behaviours and lipoprotein particle subclass profiles in a middle-to older-aged population

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dc.contributor.author Millar, Seán R.
dc.contributor.author Harrington, Janas M.
dc.contributor.author Perry, Ivan J.
dc.contributor.author Phillips, Catherine M.
dc.date.accessioned 2020-11-12T10:12:08Z
dc.date.available 2020-11-12T10:12:08Z
dc.date.issued 2020-10-08
dc.identifier.citation Millar, S. R., Harrington, J. M., Perry, I. J. and Phillips, C. M. (2020) ‘Protective lifestyle behaviours and lipoprotein particle subclass profiles in a middle-to older-aged population’, Atherosclerosis, 314, pp. 18-26, doi: 10.1016/j.atherosclerosis.2020.10.005 en
dc.identifier.volume 314 en
dc.identifier.startpage 18 en
dc.identifier.endpage 26 en
dc.identifier.issn 0021-9150
dc.identifier.uri http://hdl.handle.net/10468/10751
dc.identifier.doi 10.1016/j.atherosclerosis.2020.10.005 en
dc.description.abstract Background and aims: Lipoprotein particle size is associated with increased atherosclerosis and cardiovascular disease risk. Certain lifestyle behaviours may be cardioprotective. We examined lipoprotein particle size and concentration relationships with a protective lifestyle behaviour (PLB) score. Methods: This was a cross-sectional analysis of 2045 middle-to older-aged adults. Lipoprotein particle subclass size and concentrations were determined using nuclear magnetic resonance spectroscopy. Five protective behaviours included never smoking, moderate alcohol intake, moderate to vigorous physical activity, a high-quality diet (upper 40% Dietary Approaches to Stop Hypertension score) and a normal body mass index (BMI) (18.5–24.9 kg/m2). Linear and logistic regression analyses tested individual protective behaviour and PLB score associations with lipoprotein subclasses. Results: Individual behaviour associations varied according to lipoprotein subclass, with normal BMI showing the greatest number of significant relationships. Logistic regression analyses revealed that subjects with the fewest number of protective behaviours had 1.4–2.8 increased odds of having less favourable lipoprotein profiles defined as above or below median level lipoprotein particle subclass size or concentration. Following additional adjustment for BMI, significant trend relationships were observed between the PLB score and large and medium very low-density lipoprotein (p = 0.001 and p < 0.001), total and smaller low-density lipoprotein (LDL) concentrations (p = 0.008 and p < 0.001), LDL size (p = 0.003) and a lipoprotein insulin resistance score (p = 0.003). Conclusions: Results show a cumulative protective effect of healthy lifestyle behaviours against an unfavourable potentially pro-atherogenic lipoprotein profile in middle-to older-aged adults, highlighting the importance of lifestyle promotion in healthy ageing. en
dc.description.sponsorship Health Research Board (HRC/2007/13); Breakthrough Cancer Research, Ireland (BCR-2018-07 PH-UCC) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier B.V. en
dc.rights © 2020, the Authors. Published by Elsevier B.V. This article is made available under the CC BY 4.0 license. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Protective en
dc.subject Behaviours en
dc.subject Lipoproteins en
dc.subject Subclasses en
dc.subject Profiles en
dc.title Protective lifestyle behaviours and lipoprotein particle subclass profiles in a middle-to older-aged population en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Seán Millar, HRB Centre for Health and Diet Research, Public Health, University College Cork, Cork, Ireland. T: +353-21-490-3000 E: s.millar@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Health Research Board en
dc.contributor.funder Breakthrough Cancer Research, Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Atherosclerosis en
dc.internal.IRISemailaddress s.millar@ucc.ie en


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© 2020, the Authors. Published by Elsevier B.V. This article is made available under the CC BY 4.0 license. Except where otherwise noted, this item's license is described as © 2020, the Authors. Published by Elsevier B.V. This article is made available under the CC BY 4.0 license.
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