Chronic intermittent hypoxia impairs diuretic and natriuretic responses to volume expansion in rats with preserved low-pressure baroreflex control of the kidney

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dc.contributor.author AlMarabeh, Sara
dc.contributor.author O'Neill, Julie
dc.contributor.author Cavers, Jeremy
dc.contributor.author Lucking, Eric F.
dc.contributor.author O'Halloran, Ken D.
dc.contributor.author Abdulla, Mohammed H.
dc.date.accessioned 2020-11-19T11:22:36Z
dc.date.available 2020-11-19T11:22:36Z
dc.date.issued 2020-11-09
dc.identifier.citation AlMarabeh, S., O'Neill, J., Cavers, J., Lucking, E. F., O'Halloran, K. D., Abdulla, M. H. (2020) 'Chronic intermittent hypoxia impairs diuretic and natriuretic responses to volume expansion in rats with preserved low-pressure baroreflex control of the kidney', American Journal of Physiology - Renal Physiology. doi: 10.1152/ajprenal.00377.2020 en
dc.identifier.issn 1931-857X
dc.identifier.uri http://hdl.handle.net/10468/10777
dc.identifier.doi 10.1152/ajprenal.00377.2020 en
dc.description.abstract We examined the effects of exposure to chronic intermittent hypoxia (CIH) on baroreflex control of renal sympathetic nerve activity (RSNA) and renal excretory responses to volume expansion (VE) before and after intra-renal TRPV1 blockade by capsaizepine (CPZ). Male Wistar rats were exposed to 96 cycles of hypoxia per day for 14 days (CIH), or normoxia. Urine flow and absolute Na+ excretion during VE were less in CIH-exposed rats, but the progressive decrease in RSNA during VE was preserved. Assessment of the high-pressure baroreflex revealed an increase in the operating and response range of RSNA and decreased slope in CIH-exposed rats with substantial hypertension (+19mmHg basal mean arterial pressure, MAP), but not in a second cohort with modest hypertension (+12mmHg). Intra-renal CPZ caused diuresis, natriuresis and a reduction in MAP in sham and CIH-exposed rats. Following intra-renal CPZ, diuretic and natriuretic responses to VE in CIH-exposed rats were equivalent to sham. TPRV1 expression in the renal pelvic wall was similar in both experimental groups. Exposure to CIH did not elicit glomerular hypertrophy, renal inflammation or oxidative stress. We conclude that exposure to CIH: 1) does not impair the low-pressure baroreflex control of RSNA; 2) has modest effects on the high-pressure baroreflex control of RSNA, most likely indirectly due to hypertension; 3) can elicit hypertension in the absence of kidney injury; and 4) impairs diuretic and natriuretic responses to fluid overload. Our results suggest that exposure to CIH causes renal dysfunction, which may be relevant to obstructive sleep apnea. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Physiological Society en
dc.rights © 2020, American Physiological Society. All rights reserved. This is a post-peer-review, pre-copyedit version of an article published in American Journal of Physiology - Renal Physiology. The final authenticated version is available online at: https://doi.org/10.1152/ajprenal.00377.2020 en
dc.subject Intermittent hypoxia en
dc.subject Baroreflex en
dc.subject Volume expansion en
dc.subject Diuresis en
dc.subject TPRV1 en
dc.title Chronic intermittent hypoxia impairs diuretic and natriuretic responses to volume expansion in rats with preserved low-pressure baroreflex control of the kidney en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Mohammed Abdulla, Physiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: m.abdulla@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2021-11-09
dc.date.updated 2020-11-19T11:09:28Z
dc.description.version Accepted Version en
dc.internal.rssid 544490982
dc.internal.pmid 33166181
dc.contributor.funder University College Cork en
dc.contributor.funder University of Jordan en
dc.description.status Peer reviewed en
dc.identifier.journaltitle American Journal of Physiology - Renal Physiology en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress m.abdulla@ucc.ie en
dc.internal.bibliocheck In press. Check vol / issue / page range. Amend citation and copyright statement as necessary. en
dc.identifier.eissn 1522-1466


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