• Quinacrine and niclosamide promote neurite growth in midbrain dopaminergic neurons through the canonical BMP-Smad pathway and protect against neurotoxin and a-synuclein-induced neurodegeneration 

  Goulding, Susan R.; Lévesque, Martin; Sullivan, Aideen M.; Collins, Louise M.; O'Keeffe, Gerard W. (Springer, 2021-03-12)

  Parkinson's disease is a neurodegenerative disorder characterised by nigrostriatal dopaminergic degeneration, and intracellular a-synuclein aggregation. Current pharmacological treatments are solely symptomatic so there ...
• Effects of intracerebroventricular leptin and orexin-A on the baroreflex control of renal sympathetic nerve activity in conscious rats fed a normal or high-fat diet 

  Huang, Chunlong; AlMarabeh, Sara; Cavers, Jeremy; Abdulla, Mohammed H.; Johns, Edward J. (John Wiley & Sons, Inc., 2020-12-22)

  This study examined the effect of leptin and orexin‐A on autonomic baroreflex control in conscious Wistar rats exposed to high‐fat (45% fat) or normal (3.4%) diet for 4 weeks. Renal sympathetic nerve activity (RSNA), mean ...
• Optimisation of gene editing for cystic fibrosis 

  Mention, Karen (University College Cork, 2020-06-06)

  Cystic Fibrosis (CF) is a recessive genetic disease caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. To date, 352 variants in the CFTR gene have been shown to be CF-causing. CF ...
• Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer 

  Keane, Jonathan M.; Joyce, Susan A.; Gahan, Cormac G. M.; Hyland, Niall P.; Houston, Aileen (Springer Nature Switzerland AG, 2020-12-03)

  The symbiosis between the gut microbiota and the host has been identified as an integral part of normal human physiology and physiological development. Research in germ-free or gnotobiotic animals has demonstrated the ...
• Chronic intermittent hypoxia impairs diuretic and natriuretic responses to volume expansion in rats with preserved low-pressure baroreflex control of the kidney 

  AlMarabeh, Sara; O'Neill, Julie; Cavers, Jeremy; Lucking, Eric F.; O'Halloran, Ken D.; Abdulla, Mohammed H. (American Physiological Society, 2020-11-09)

  We examined the effects of exposure to chronic intermittent hypoxia (CIH) on baroreflex control of renal sympathetic nerve activity (RSNA) and renal excretory responses to volume expansion (VE) before and after intra-renal ...

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