• Sensorimotor control of breathing in the mdx mouse model of Duchenne muscular dystrophy 

  Burns, David P.; Roy, Arijit; Lucking, Eric; McDonald, Fiona B.; Gray, Sam; Wilson, Richard J.; Edge, Deirdre; O'Halloran, Ken D. (John Wiley & Sons, Inc., 2017-09-26)

  Patients with Duchenne muscular dystrophy (DMD) hypoventilate with consequential arterial blood gas derangement relevant to disease progression. Whereas deficits in DMD diaphragm are recognized, there is a paucity of ...
• Intrarenal Mas and AT(1) receptors play a role in mediating the excretory actions of renal interstitial angiotensin-(1-7) infusion in anaesthetized rats 

  O'Neill, Julie; Healy, Vincent; Johns, Edward J. (John Wiley & Sons, Inc., 2017-09-21)

  New Findings What is the central question of this study? Dietary sodium manipulation alters the magnitude of angiotensin‐(1–7) [Ang‐(1–7)]‐induced natriuresis. The present study sought to determine whether this was related ...
• Diaphragm muscle weakness following acute sustained hypoxic stress in the mouse is prevented by pretreatment with N-acetyl cysteine 

  O'Leary, Andrew J.; Drummond, Sarah E.; Edge, Deirdre; O'Halloran, Ken D. (Hindawi Ltd., 2018)

  Oxygen deficit (hypoxia) is a major feature of cardiorespiratory diseases characterized by diaphragm dysfunction, yet the putative role of hypoxic stress as a driver of diaphragm dysfunction is understudied. We explored ...
• Development of an ex vivo method for multi-unit recording of microbiota-colonic-neural signaling in real time 

  Buckley, Maria M.; O'Malley, Dervla (Frontiers Media SA, 2018)

  Background and Objectives: Bidirectional signaling between the gastrointestinal tract and the brain is vital for maintaining whole-body homeostasis. Moreover, emerging evidence implicates vagal afferent signaling in the ...
• Interaction between nitric oxide and renal α1-adrenoreceptors mediated vasoconstriction in rats with left ventricular hypertrophyin Wistar Kyoto rats 

  Ahmad, Ashfaq; Sattar, Munavvar A.; Azam, Maleeha; Khan, Safia A.; Bhatt, Owais; Johns, Edward J. (Public Library of Science, 2018)

  Left ventricular hypertrophy (LVH) is associated with decreased responsiveness of renal alpha(1)-adrenoreceptors subtypes to adrenergic agonists. Nitric oxide donors are known to have antihypertrophic effects however their ...

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