• Investigating the role of interleukin-6 in neuronal dysfunction in the mdx mouse model of Duchenne muscular dystrophy 

  Stephenson, Kimberley Alix (University College Cork, 2022-01-07)

  Duchenne Muscular Dystrophy (DMD) is a fatal musculoskeletal disorder that results in a loss of dystrophin in muscle fibres, leading to progressive immobility, chronic inflammation and premature death. Inflammation is ...
• Investigation of the gut microbiome, bile acid composition and host immunoinflammatory response in a model of azoxymethane-induced colon cancer at discrete timepoints 

  Keane, Jonathan M.; Walsh, Calum J.; Cronin, P.; Baker, Kevin J.; Melgar, Silvia; Cotter, Paul D.; Joyce, Susan A.; Gahan, Cormac G. M.; Houston, Aileen M.; Hyland, Niall P. (Springer Nature, 2022-11-23)

  Background: Distinct sets of microbes contribute to colorectal cancer (CRC) initiation and progression. Some occur due to the evolving intestinal environment but may not contribute to disease. In contrast, others may play ...
• Development of novel therapeutics for all individuals with CF (the future goes on) 

  Amaral, Margarida D.; Harrison, Patrick T. (Elsevier B.V., 2022-10-30)

  Despite the major advances and successes in finding and establishing new treatments that tackle the basic defect in Cystic Fibrosis (CF), there is still an unmet need to bring these potentially curative therapies to all ...
• Impact of cancer cachexia on respiratory muscle function and the therapeutic potential of exercise 

  Murphy, Ben T.; Mackrill, John J.; O'Halloran, Ken D. (John Wiley & Sons, Inc., 2022-10-17)

  Cancer cachexia is defined as a multi-factorial syndrome characterised by an ongoing loss of skeletal muscle mass and progressive functional impairment, estimated to affect 50–80% of patients and responsible for 20% of ...
• A framework for AI-assisted detection of Patent Ductus Arteriosus from neonatal phonocardiogram 

  Gómez-Quintana, Sergi; Schwarz, Christoph E.; Shelevytsky, Ihor; Shelevytska, Victoriya; Semenova, Oksana; Factor, Andreea; Popovici, Emanuel; Temko, Andriy (MDPI, 2021-02-05)

  The current diagnosis of Congenital Heart Disease (CHD) in neonates relies on echocardiography. Its limited availability requires alternative screening procedures to prioritise newborns awaiting ultrasound. The routine ...

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