Wu, Sen; Mariotti, Marco; Santesmasses, Didac; Hill, Kristina E.; Baclaocos, Janinah; Aparicio-Prat, Estel; Li, Shuping; Mackrill, John; Wu, Yuanyuan; Howard, Michael T.; Capecchi, Mario; Guigó, Roderic; Burk, Raymond F.; Atkins, John F.(The Royal Society, 2016-11-23)
Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3′ UTR structural elements (SECIS) and is regulated by selenium availability. ...
Respiratory muscle metaboreflexes exert substantial influence over cardiorespiratory and autonomic control, exemplified during heavy dynamic exercise in health, and in obstructive airways disease even at rest.
O'Halloran, Ken D.(John Wiley & Sons, Inc., 2018-01-26)
The homeostatic regulation of blood pressure depends on an exquisite interplay between multimodal sensors, several brain regions and long-range control systems that serve to maintain and defend cardiovascular constancy.
Burns, David P.; Ali, Izza; Rieux, Clement; Healy, James; Jasionek, Greg; O'Halloran, Ken D.(MDPI AG, 2017)
Duchenne muscular dystrophy (DMD) is characterized by striated muscle weakness, cardiomyopathy, and respiratory failure. Since oxidative stress is recognized as a secondary pathology in DMD, the efficacy of antioxidant ...
Harrison, Patrick T.; Hart, Stephen(Wiley, 2017-12-28)
Genome editing enables precise changes to be made in the genome of living cells. The technique was originally developed in the 1980′s but largely limited to use in mice. The discovery that a targeted double stranded break ...
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