• Investigating neuronal calcium homeostasis in murine models of Alzheimer’s disease 

  Kaar, Aidan (University College Cork, 2019)

  This thesis is primarily concerned with the pathological remodelling of calcium homeostasis and signalling in murine Alzheimer’s disease (AD) models, namely the 3xTg-AD (APPSWE/PS1M146V/TauP301L) mouse and TgF344-AD ...
• Renal cortical oxygen tension is decreased following exposure to long-term but not short-term intermittent hypoxia in the rat 

  O'Neill, Julie; Jasionek, Greg; Drummond, Sarah E.; Brett, Orla; Lucking, Eric F.; Abdulla, Mohammed A.; O'Halloran, Ken D. (American Physiological Society, 2019-01-16)

  Chronic kidney disease (CKD) occurs in more than 50% of patients with obstructive sleep apnea (OSA). However, the impact of intermittent hypoxia (IH) on renal function and oxygen homeostasis is unclear. Male Sprague Dawley ...
• Endocrine regulation of gut function - a role for glucagon-like peptide-1 in the pathophysiology of irritable bowel syndrome 

  O'Malley, Dervla (John Wiley & Sons, Inc., 2018-11-16)

  The prevalent and debilitating functional bowel disorder, irritable bowel syndrome (IBS), is characterized by symptoms that include abdominal pain, bloating, diarrhoea and/or constipation. The heterogeneity of IBS underscores ...
• Inspiratory pressure-generating capacity is preserved during ventilatory and non-ventilatory behaviours in young dystrophic mdx mice despite profound diaphragm muscle weakness 

  Burns, David P; Murphy, Kevin H.; Lucking Eric F.; O'Halloran Ken D. (Wiley, 2018-12-20)

  Diaphragm dysfunction is recognized in the mdx mouse model of muscular dystrophy, however there is a paucity of information concerning the neural control of dystrophic respiratory muscles. In young adult (8 weeks of age) ...
• When pharmacology meets the microbiome: new targets for therapeutics? 

  Hyland, Niall P.; Cryan, John F. (British Pharmacological Society, 2018-11-26)

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