Silicon photonics-based laser Doppler vibrometer array for carotid-femoral pulse wave velocity (PWV) measurement

Li, Yanlu; Marais, Louise; Khettab, Hakim; Quan, Zhiheng; Aasmul, Soren; Leinders, Rob; Schüler, Ralf; Morrissey, Padraic E.; Greenwald, Stephen; Segers, Patrick; Vanslembrouck, Michael; Bruno, Rosa M.; Boutouyrie, Pierre; O'Brien, Peter; de Melis, Mirko; Baets, Roel

Silicon photonics-based laser Doppler vibrometer array for carotid-femoral pulse wave velocity (PWV) measurement

Files

boe-11-7-3913.pdf(2.07 MB)

Published Version

Date

2020-06-22

Authors

Li, Yanlu

Marais, Louise

Khettab, Hakim

Quan, Zhiheng

Aasmul, Soren

Leinders, Rob

Schüler, Ralf

Morrissey, Padraic E.

Greenwald, Stephen

Segers, Patrick

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Publisher

Optical Society of America

Published Version

10.1364/BOE.394921

Abstract

Pulse wave velocity (PWV) is a reference measure for aortic stiffness, itself an important biomarker of cardiovascular risk. To enable low-cost and easy-to-use PWV measurement devices that can be used in routine clinical practice, we have designed several handheld PWV sensors using miniaturized laser Doppler vibrometer (LDV) arrays in a silicon photonics platform. The LDV-based PWV sensor design and the signal processing protocol to obtain pulse transit time (PTT) and carotid-femoral PWV in a feasibility study in humans, are described in this paper. Compared with a commercial reference PWV measurement system, measuring arterial pressure waveforms by applanation tonometry, LDV-based displacement signals resulted in more complex signals. However, we have shown that it is possible to identify reliable fiducial points for PTT calculation using the maximum of the 2nd derivative algorithm in LDV-based signals, comparable to those obtained by the reference technique, applanation tonometry.

Keywords

Pulse wave velocity , PWV , Aortic stiffness , Cardiovascular risk , Clinical practice , Handheld PWV sensor , Laser Doppler vibrometer , LDV , Silicon photonics platform

Citation

Li, Y., Marais, L., Khettab, H., Quan, Z., Aasmul, S., Leinders, R., Schüler, R., Morrissey, P. E., Greenwald, S., Segers, P., Vanslembrouck, M., Bruno, R. M., Boutouyrie, P., O'Brien, P., de Melis, M. and Baets, R. (2020) 'Silicon photonics-based laser Doppler vibrometer array for carotid-femoral pulse wave velocity (PWV) measurement', Biomedical Optics Express, 11(7), pp. 3913-3926. doi: 10.1364/BOE.394921