On the association between circulating biomarkers and atherosclerotic calcification in a cohort of arterial disease participants

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dc.contributor.author Cahalane, Rachel M.
dc.contributor.author Barrett, Hilary E.
dc.contributor.author Ross, Aisling M.
dc.contributor.author Mulvihill, John J. E.
dc.contributor.author Purtill, Helen
dc.contributor.author Selvarajah, Logeswaran
dc.contributor.author O’Brien, Julie
dc.contributor.author Kavanagh, Eamon G.
dc.contributor.author Moloney, Michael A.
dc.contributor.author Egan, Siobhan M.
dc.contributor.author Leahy, Fiona C.
dc.contributor.author Griffin, Tomás P.
dc.contributor.author Islam, Md. Nahidul
dc.contributor.author O’Shea, Paula M.
dc.contributor.author Walsh, Michael T.
dc.contributor.author O’Connor, Eibhlís M.
dc.date.accessioned 2021-04-12T09:41:19Z
dc.date.available 2021-04-12T09:41:19Z
dc.date.issued 2021-02-14
dc.identifier.citation Cahalane, R. M., Barrett, H. E., Ross, A. M., Mulvihill, J. J., Purtill, H., Selvarajah, L., O’Brien, J., Kavanagh, E. G., Moloney, M. A., Egan, S. M. and Leahy, F. C. (2021) 'On the association between circulating biomarkers and atherosclerotic calcification in a cohort of arterial disease participants', Nutrition, Metabolism and Cardiovascular Diseases. doi: 10.1016/j.numecd.2021.02.005 en
dc.identifier.issn 0939-4753
dc.identifier.uri http://hdl.handle.net/10468/11189
dc.identifier.doi 10.1016/j.numecd.2021.02.005 en
dc.description.abstract Background and Aims: Atherosclerotic calcification is a powerful predictor of cardiovascular disease. This study aims to determine whether circulating levels of a local/systemic calcification inhibitor or a marker of bone formation correlate with measures of coronary or extracoronary calcification. Methods and Results: Clinical computed tomography (CT) was performed on 64 arterial disease participants undergoing carotid and lower extremity endarterectomy. Coronary artery calcium (CAC) scores and volumes were acquired from the CT scans (n = 42). CAC scores and volumes were used to derive CAC density scores. Micro-CT was performed on excised carotid (n = 36) and lower extremity (n = 31) plaques to quantify the volume and volume fraction of extracoronary calcification. Circulating levels of dephospho-uncarboxylated Matrix Gla Protein (dp-ucMGP), fetuin-A, carboxylated and uncarboxylated osteocalcin (ucOC) were quantified using commercial immunoassays. Carotid participant CAC density scores were moderately negatively correlated with plasma dp-ucMGP (rs = -0.592, P = 0.008). A weak negative association was found between CAC scores and %ucOC for all participants (rs = -0.335, P = 0.040). Another weak negative correlation was observed between fetuin-A and the volume of calcification within excised carotid specimens (rs = -0.366, P = 0.031). Despite substantial differences in coronary and extracoronary calcium measurements, the levels of circulating biomarkers did not vary significantly between carotid and lower extremity subgroups. Conclusion: Correlations identified between circulating biomarkers and measures of coronary and extracoronary calcium were not consistent among participant subgroups. Further research is required to determine the association between circulating biomarkers, coronary and extracoronary calcium. en
dc.description.sponsorship Irish Research Council (GOIPG/2016/1554; GOIPG/2013/1309; New Foundations Scheme: BioVascCalc); Irish Heart Foundation (Stroke Prevention Research Bursary Award: 1102357); University of Limerick (Health Research Institute Seed Funding Programme Award) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier B.V. en
dc.rights © 2021, The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department ofClinicalMedicine and Surgery, Federico II University. Published by Elsevier B.V. This is an open access article under the CC BY license. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Matrix Gla Protein en
dc.subject Fetuin-A en
dc.subject Osteocalcin en
dc.subject Diagnostic testing en
dc.subject Computed tomography en
dc.subject Cardiovascular disease en
dc.title On the association between circulating biomarkers and atherosclerotic calcification in a cohort of arterial disease participants en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Eibhlís M. O’Connor, APC Microbiome Institute, University College Cork, Cork, Ireland. T: +353-21- 490-3000 en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Irish Research Council en
dc.contributor.funder Irish Heart Foundation en
dc.contributor.funder University of Limerick en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Nutrition, Metabolism and Cardiovascular Diseases en
dc.internal.bibliocheck In press. Check vol / issue / page range. Amend citation as necessary. Upload PV under CC BY. en


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© 2021, The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department ofClinicalMedicine and Surgery, Federico II University. Published by Elsevier B.V. This is an open access article under the CC BY license. Except where otherwise noted, this item's license is described as © 2021, The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department ofClinicalMedicine and Surgery, Federico II University. Published by Elsevier B.V. This is an open access article under the CC BY license.
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