Microbial diversity in the human intestine and novel insights from metagenomics
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Accepted Version
Date
2009-01-01
Authors
Ventura, Marco
Turroni, Francesca
Canchaya, Carlos
Vaughan, Elaine E.
O'Toole, Paul W.
van Sinderen, Douwe
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers In Bioscience
Published Version
Abstract
Bacterial communities reside in very different ecological niches on and within the human host, such as those associated with the alimentary tract. The human gastrointestinal tract is populated with as many as 100 trillion bacterial cells, whose collective genome likely reflects the co-evolution between the microbial community and its host. Recent progress has highlighted the intriguing diversity of these bacterial populations and their important contributions to human physiology. Thus, a thorough understanding of the autochthonous component of the intestinal microbiota is expected to provide crucial information not only on how to develop therapies for various gastrointestinal diseases but also on how to choose the next generation of probiotic bacteria as part of novel functional foods. Recently, novel culture-independent approaches such as metagenomics-based techniques were shown to be crucially important for the exploration of the biodiversity of the human intestinal microbiota.
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Keywords
Intestinal microbiota , Metagenomics , Novel probiotic , Probiotic bacteria
Citation
Ventura, M, Turroni, F, Canchaya, C, Vaughan, EE, O'Toole, PW, van Sinderen, D (2009) 'Microbial Diversity In The Human Intestine and Novel Insights From Metagenomics'. Frontiers In Bioscience, 14 (1):3214-3863.
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© Frontiers in Bioscience