Powering up microbiome-microglia interactions.

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Date
2021-11-02
Authors
Lynch, Caoimhe M. K.
Clarke, Gerard
Cryan, John F.
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Publisher
Elsevier
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Abstract
Despite extensive evidence implicating the microbiota in regulating the immune system, the precise mechanisms underlying microbial control of microglial maturation remain unclear. In a methodological tour de force, Erny et al. (2021) identify acetate as an essential microbiota-derived molecule driving microglial metabolic pathways and functions during healthy and diseased states.
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Keywords
Gastrointestinal microbiome , Microbiota , Microglia , Neurogenesis , Intestine flora , Microflora , Microglia , Nervous system development
Citation
Lynch, C. M. K., Clarke, G. and Cryan, J. F. (2021) ‘Powering up microbiome-microglia interactions’, Cell Metabolism, 33(11), pp. 2097-2099. doi: 10.1016/j.cmet.2021.10.006