Novel insights into the inflammatory basis of gastrointestinal disease

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dc.contributor.advisor Nally, Kenneth en
dc.contributor.advisor Cryan, John F. en Moloney, Gerard M. 2014-06-18T11:35:32Z 2013 2013
dc.identifier.citation Moloney, G. 2013. Novel insights into the inflammatory basis of gastrointestinal disease. PhD Thesis, University College Cork. en
dc.description.abstract It has become clear that inflammation is beneficial to man, there are situations though that the inflammatory response causes damage to the host that is harmful to health. When the inflammatory response fails or is too strong, the health of the host is damaged and disease can occur. The implication of intestinal disease caused by an ineffective immune response is of great social and economic burden to society. The overarching purpose of this thesis is to assess inflammatory signalling targets associated with immune mediated disorders such as IBD, IBS and inflammatory liver disease. By assessing these targets and modifying their function I hope to contribute and expand further the pre-existing information on these disorders and improve the therapeutic interventions available in these debilitating conditions. I will assess the role of inflammation in disorders of the GI tract and liver IBD, IBS, hepatic inflammatory injury and furthermore, I will use pharmaceutical agents to activate and suppress components of the immune system. I will examine the inflammatory response in experimental models of disease for IBD and liver injury, I will attempt to alter these pathways using pharmaceutical intervention to delineate the disease causing mechanism that may lead to clinically relevant therapeutic interventions. In regards to IBS, I will attempt to improve the existing knowledge that exists in relation to the pathogenesis of this functional bowel disorder. I will attempt to define a mechanism by which the low grade mucosal inflammation that has been demonstrated by others arises and what this inflammation is induced by. The overall aim of this thesis is to attempt to further understand the mechanisms behind GI and liver disease. Looking at the inflammatory response in these specific conditions and how they can be altered may lead to exciting new therapies for inflammatory conditions in the gastrointestinal tract. en
dc.description.sponsorship Science Foundation Ireland (02/CE/B124); Science Foundation Ireland (07/CE/B1368) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2013, Gerard Moloney. en
dc.rights.uri en
dc.subject Inflammation en
dc.subject Epigenetics en
dc.subject Bromodomain en
dc.subject Interferon en
dc.subject Mucosal immunity en
dc.subject Nuclear receptors en
dc.subject Inflammatory bowel disease en
dc.subject Irritable bowel syndrome en
dc.title Novel insights into the inflammatory basis of gastrointestinal disease en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Medicine and Health) en
dc.internal.availability Full text not available en Indefinite en 10000-01-01
dc.description.version Accepted Version
dc.contributor.funder Science Foundation Ireland en
dc.description.status Not peer reviewed en Alimentary Pharmabotic Centre en Anatomy en
dc.check.reason Releasing this thesis would cause substantial prejudice to the commercial interests of the sponsor of the postgraduate research en
dc.check.opt-out Yes en
dc.thesis.opt-out true
dc.check.entireThesis Entire Thesis Restricted
dc.check.embargoformat Both hard copy thesis and e-thesis en
dc.internal.conferring Spring Conferring 2014 en

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© 2013, Gerard Moloney. Except where otherwise noted, this item's license is described as © 2013, Gerard Moloney.
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