Oscillometric measure of blood pressure detects association between orthostatic hypotension and depression in population based study of older adults

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dc.contributor.author O'Regan, Claire
dc.contributor.author Kearney, Patricia M.
dc.contributor.author Cronin, Hilary
dc.contributor.author Savva, George M.
dc.contributor.author Lawlor, Brian A.
dc.contributor.author Kenny, Rose Anne
dc.date.accessioned 2016-02-08T13:27:15Z
dc.date.available 2016-02-08T13:27:15Z
dc.date.issued 2013-10-18
dc.identifier.citation O REGAN, C., KEARNEY, P. M., CRONIN, H., SAVVA, G. M., LAWLOR, B. A. & KENNY, R. 2013. Oscillometric measure of blood pressure detects association between orthostatic hypotension and depression in population based study of older adults. BMC Psychiatry, 13:266, 1-8. http://dx.doi.org/10.1186/1471-244X-13-266 en
dc.identifier.volume 13 en
dc.identifier.startpage 1 en
dc.identifier.endpage 8 en
dc.identifier.issn 1471-244X
dc.identifier.uri http://hdl.handle.net/10468/2262
dc.identifier.doi 10.1186/1471-244x-13-266
dc.description.abstract Background: White matter hyperintensities may contribute to depression by disrupting neural connections among brain regions that regulate mood. Orthostatic hypotension (OH) may be a risk factor for white matter hyperintensities and accumulating evidence, although limited suggests it may play a role in the development of late-life depression. The aim of this study was to examine the relationship between an oscillometric measure of orthostatic hypotension and depression in population based sample of older adults. Methods: We analysed data on adults aged 60 and over from the first wave of The Irish Longitudinal Study on Ageing (TILDA). Depression was assessed using the Center for Epidemiologic Studies – Depression (CES–D) scale and OH was assessed by a sit-to-stand orthostatic stress test; two seated blood pressure measurements were followed by a single standing blood pressure measurement. Participants self reported whether they felt dizzy, light-headed or unsteady on standing. Results: Participants with symptomatic OH (SOH, n=20) had the highest mean CES-D score (mean 8.6, SE 1.6) when compared to participants with asymptomatic OH (AOH) (mean 5.6, SE .48) and participants with no OH (mean 5.2, SE .14) and this difference was significant for both comparisons (p<0.001). Linear regression analysis adjusted for socio-demographic and clinical characteristics showed that SOH was associated with higher CES-D scores (unstandardised B coefficient = 2.24; 95% CI .301 - 4.79; p =0.05) compared to participants without OH. AOH was not associated with higher CES-D scores (unstandardised B coefficient =.162; 95% CI -.681, 1.00; p= 0.70). Conclusions: Symptomatic orthostatic hypotension is associated with depression in older adults and needs to be considered in studies examining the relationship between vascular disease and depression in older adults. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BioMed Central Ltd. en
dc.rights © O Regan et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.rights.uri http://​creativecommons.​org/​licenses/​by/​2.​0 en
dc.subject White-matter hyperintensities en
dc.subject Late-life depression en
dc.subject Vascular depression en
dc.subject Heart disease en
dc.subject Symptoms en
dc.subject Epidemiology en
dc.subject Hypertension en
dc.subject Prevalence en
dc.subject Hypothesis en
dc.subject Diagnosis en
dc.title Oscillometric measure of blood pressure detects association between orthostatic hypotension and depression in population based study of older adults en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Patricia Kearney, Department of Epidemiology and Public Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: patricia.kearney@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Atlantic Philanthropies
dc.contributor.funder Irish Life plc
dc.contributor.funder Irish Government
dc.description.status Peer reviewed en
dc.identifier.journaltitle BMC Psychiatry en
dc.internal.IRISemailaddress patricia.kearney@ucc.ie en
dc.identifier.articleid 266


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© O Regan et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as © O Regan et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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