The DSF family of cell-cell signals: an expanding class of bacterial virulence regulators

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dc.contributor.author Ryan, Robert P.
dc.contributor.author An, Shi-Qi
dc.contributor.author Allan, John H.
dc.contributor.author McCarthy, Yvonne
dc.contributor.author Dow, J. Maxwell
dc.date.accessioned 2016-02-17T10:07:57Z
dc.date.available 2016-02-17T10:07:57Z
dc.date.issued 2015
dc.identifier.citation Ryan RP, An S-q, Allan JH, McCarthy Y, Dow JM (2015) The DSF Family of Cell–Cell Signals: An Expanding Class of Bacterial Virulence Regulators. PLoS Pathog 11(7): e1004986. doi:10.1371/journal.ppat.1004986
dc.identifier.volume 11 en
dc.identifier.issued 7 en
dc.identifier.issn 1553-7366
dc.identifier.uri http://hdl.handle.net/10468/2304
dc.identifier.doi 10.1371/journal.ppat.1004986
dc.description.abstract Many pathogenic bacteria use cell-cell signaling systems involving the synthesis and perception of diffusible signal molecules to control virulence as a response to cell density or confinement to niches. Bacteria produce signals of diverse structural classes. Signal molecules of the diffusible signal factor (DSF) family are cis-2-unsaturated fatty acids. The paradigm is cis-11-methyl-2-dodecenoic acid from Xanthomonas campestris pv. campestris (Xcc), which controls virulence in this plant pathogen. Although DSF synthesis was thought to be restricted to the xanthomonads, it is now known that structurally related molecules are produced by the unrelated bacteria Burkholderia cenocepacia and Pseudomonas aeruginosa. Furthermore, signaling involving these DSF family members contributes to bacterial virulence, formation of biofilms and antibiotic tolerance in these important human pathogens. Here we review the recent advances in understanding DSF signaling and its regulatory role in different bacteria. These advances include the description of the pathway/mechanism of DSF biosynthesis, identification of novel DSF synthases and new members of the DSF family, the demonstration of a diversity of DSF sensors to include proteins with a Per-Arnt-Sim (PAS) domain and the description of some of the signal transduction mechanisms that impinge on virulence factor expression. In addition, we address the role of DSF family signals in interspecies signaling that modulates the behavior of other microorganisms. Finally, we consider a number of recently reported approaches for the control of bacterial virulence through the modulation of DSF signaling. en
dc.description.sponsorship Wellcome Trust, United Kingdom (Senior Fellowship Grant WT100204AIA); European Commission (Seventh Framework Programme Grant No. 603038) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Public Library of Science en
dc.rights © 2015 Ryan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Quorum sensing signal en
dc.subject Oryzae pv. oryzicola en
dc.subject Cyclic di-GMP en
dc.subject Gyp domain protein en
dc.subject Citri subsp citri en
dc.subject Xanthomonas campestris en
dc.subject Xylella fastidiosa en
dc.subject Stenotrophomonas maltophilia en
dc.subject Burkholderia cenocepacia en
dc.subject Pseudomonas aeruginosa en
dc.title The DSF family of cell-cell signals: an expanding class of bacterial virulence regulators en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Max Dow, School of Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: m.dow@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.internal.wokid WOS:000359365200021
dc.contributor.funder Wellcome Trust, United Kingdom
dc.contributor.funder European Commission
dc.description.status Peer reviewed en
dc.identifier.journaltitle PLOS PATHOGENS en
dc.internal.IRISemailaddress m.dow@ucc.ie en
dc.identifier.articleid e1004986


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© 2015 Ryan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Except where otherwise noted, this item's license is described as © 2015 Ryan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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