Synthesis & retention mechanisms of novel mixed mode stationary phase for detection of specific polar low molecular weight biological samples

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dc.contributor.advisor Glennon, Jeremy D. en
dc.contributor.author Browne, Damian
dc.date.accessioned 2016-07-14T08:36:36Z
dc.date.available 2016-07-14T08:36:36Z
dc.date.issued 2013
dc.date.submitted 2013
dc.identifier.citation Browne, D. 2013. Synthesis & retention mechanisms of novel mixed mode stationary phase for detection of specific polar low molecular weight biological samples. PhD Thesis, University College Cork. en
dc.identifier.endpage 257 en
dc.identifier.uri http://hdl.handle.net/10468/2873
dc.description.abstract The thesis primarily reports the synthesis, characterization and application of novel mixed mode stationary phases for Hydrophilic Interaction Liquid Chromatography (HILIC). HILIC is a rapidly emerging chromatographic mode that is finding great applicability in the analysis of polar organic molecules. In addition, there is a chapter on the analysis of Bisphenol A and related species using capillary electrophoresis (CE) coupled with boron-doped diamond electrodes for electrochemical detection. The synthesis and characterization of the novel mixed mode stationary phases prepared in this work is an important contribution to the field as the materials prepared exhibited better performance than similar materials obtained commercially. In addition a more thorough characterization of the materials (e.g.,thermogravimetric analysis, various NMR modes, elemental analysis, etc.) and resulting columns (e.g., H) than is typically encountered. The application of these new materials to the analysis of sugars using evaporative light scattering is also novel. In CE studies, electrochemical detection is sufficiently rare that the work is also novel. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2013, Damian Browne. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en
dc.subject Chromatography en
dc.subject Stationary phase en
dc.subject Zwitterionic en
dc.title Synthesis & retention mechanisms of novel mixed mode stationary phase for detection of specific polar low molecular weight biological samples en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Science) en
dc.internal.availability Full text available en
dc.check.info No embargo required en
dc.description.version Accepted Version
dc.description.status Not peer reviewed en
dc.internal.school Chemistry en
dc.check.type No Embargo Required
dc.check.reason No embargo required en
dc.check.opt-out No en
dc.thesis.opt-out false
dc.check.embargoformat Not applicable en
ucc.workflow.supervisor j.glennon@ucc.ie
dc.internal.conferring Spring 2014 en


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© 2013, Damian Browne. Except where otherwise noted, this item's license is described as © 2013, Damian Browne.
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