• Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia 

  Torres-Fuentes, Cristina; Pastor-Cavada, Elena; Cano, Rafael; Kandil, Dalia; Shanahan, Rachel; Juan, Rocio; Shaban, Hamdy; McGlacken, Gerard P.; Schellekens, Harriet (MDPI, 2018)

  Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart ...
• Electrochemical sensing of biotin using Nafion-modified boron-doped diamond electrode 

  Buzid, Alyah; McGlacken, Gerard P.; Glennon, Jeremy D.; Luong, John H. T. (American Chemical Society (ACS), 2018)

  Nafion formed on the surface of a boron-doped diamond electrode allows for a chemosensing system for biotin. The modified electrode is capable of oxidizing biotin and offers a detection limit of 5 nM, the average normal ...
• Will they co-crystallize? 

  Wicker, Jerome G. P.; Crowley, Lorraine M.; Robshaw, Oliver; Little, Edmund J.; Stokes, Stephen P.; Cooper, Richard I.; Lawrence, Simon E. (Royal Society of Chemistry, 2017)

  A data-driven approach to predicting co-crystal formation reduces the number of experiments required to successfully produce new co-crystals. A machine learning algorithm trained on an in-house set of co-crystallization ...
• Determination of composition distributions of multi-particle crystalline samples by sequential dissolution with concomitant particle sizing and solution analysis 

  Moynihan, Humphrey A.; Armstrong, Declan (Royal Society of Chemistry, 2018-04)

  Impurities arise in the production of molecular pharmaceutical and fine chemical products and are often addressed by crystallisation. However, impurities are not always adequately removed by crystallisations and in some ...
• Cocrystals and a salt of the bioactive flavonoid: naringenin 

  Khandavilli, Udaya Bhaskara Rao; Skořepová, Eliška; Sinha, Abhijeet S.; Bhogala, Balakrishna R.; Maguire, Nuala M.; Maguire, Anita R.; Lawrence, Simon E. (American Chemical Society, 2018-07-03)

  Cocrystallization studies on Naringenin with 27 coformers have led to the formation of five new solid forms: a piperazinium salt (PIP+-NR-) and four cocrystals with the coformers flavone (FLV), 4-hydroxypyridine (4-HP), ...

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