• Synthesis and application of phosphonothioates, phosphonodithioates, phosphorothioates, phosphinothioates and related compounds 

  Jones, David J.; O'Leary, Eileen M.; O'Sullivan, Timothy P. (Elsevier, 2018-10-26)

  Methods for the preparation of phosphonothioates, phosphonodithioates, phosphorothioates, phosphinothioates and related compounds are reviewed. The application of these compounds as synthetic intermediates is also discussed.
• Synthesis of novel quinine analogs and evaluation of their effects on Trypanosoma cruzi 

  Ceole, Ligia F.; Gandhi, Hirenkumar; Villamizar, Luz H.; Soares, Maurilio J.; O'Sullivan, Timothy P. (Future Science: Newlands Press, 2018-02)

  Aim: Chagas disease is a tropical disease caused by the hemoflagellate protozoan Trypanosoma cruzi. There is no vaccine for Chagas disease and available drugs (e.g., benznidazole) are effective only during the acute phase, ...
• Asymmetric peroxidation of α,β-unsaturated aldehydes under diarylprolinol ether catalysis 

  O'Reilly, Kate; Gupta, Manoj K.; Gandhi, Hirenkumar; Kumar, Vydyula P.; O'Sullivan, Timothy P. (Bentham Science Publishers, 2017)

  Background: Chiral peroxides, many of which are biologically active, are an attractive target in organic synthesis. Organocatalysts have been used for some time in the asymmetric epoxidation of α,β- unsaturated carbonyls. ...
• Preparation of γ,δ-unsaturated-β-ketoesters: Lewis acid-catalysed CH insertion of ethyl diazoacetate into α,β-unsaturated aldehydes 

  Gandhi, Hirenkumar; O'Sullivan, Timothy P. (Elsevier, 2017-07-29)

  The synthesis of γ,δ-unsaturated-β-keto esters was achieved by the Lewis acid-catalysed direct CH insertion of an α-diazoester into various α,β-substituted-unsaturated aldehydes. CH insertion of ethyl diazoacetate into ...
• Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia 

  Torres-Fuentes, Cristina; Pastor-Cavada, Elena; Cano, Rafael; Kandil, Dalia; Shanahan, Rachel; Juan, Rocio; Shaban, Hamdy; McGlacken, Gerard P.; Schellekens, Harriet (MDPI, 2018)

  Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart ...

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