• Major structure-activity relationships of resolvins, protectins, maresins and their analogues 

  Daly, Kevin; O'Sullivan, Killian; O'Sullivan, Timothy P. (Future Science Ltd, 2022-11-30)

  Resolvins, protectins and maresins are a series of polyunsaturated fatty acid-derived molecules which play important roles in the resolution of inflammation. They are termed specialized proresolving mediators and facilitate ...
• Pharmaceutical salts of piroxicam and meloxicam with organic counterions 

  Huang, Shan; Venables, Dean S.; Lawrence, Simon E. (ACS Publications, 2022-10-21)

  Piroxicam (PRM) and meloxicam (MEL) are two nonsteroidal anti-inflammatory drugs, belonging to the Biopharmaceutics Classification System Class II drugs. In this study, six novel pharmaceutical salts of PRM and MEL with ...
• Synthesis and reactivity of dihalofuranones 

  Lyons, Thérèse A.; Gahan, Cormac G. M.; O'Sullivan, Timothy P. (Bentham Science Publishers, 2022-08-01)

  Halogenated furanones have been found to act as potent quorum sensing inhibitors in several bacterial species. It is believed that dihalofuranones covalently bind to the LuxS enzyme, which is necessary for autoinducer-2 ...
• Genome mining and characterisation of a novel transaminase with remote stereoselectivity 

  Gavin, Declan P.; Reen, F. Jerry; Rocha-Martin, J.; Abreu-Castilla, I.; Woods, David F.; Foley, Aoife M.; Sanchez-Murcia, P. A.; Schwarz, Maria; O'Neill, P.; Maguire, Anita R.; O'Gara, Fergal (Springer Nature Switzerland AG, 2019-12-30)

  Microbial enzymes from pristine niches can potentially deliver disruptive opportunities in synthetic routes to Active Pharmaceutical Ingredients and intermediates in the Pharmaceutical Industry. Advances in green chemistry ...
• Dirhodium carboxylate catalysts from 2-fenchyloxy or 2-menthyloxy arylacetic acids: enantioselective C-H insertion, aromatic addition and oxonium ylide formation/rearrangement 

  Buckley, Aoife; Crowley, Daniel C; Brouder, Thomas A.; Ford, Alan; Khandavilli, Udaya Bhaskara Rao; Lawrence, Simon E.; Maguire, Anita R. (WILEY-VCH Verlag, 2021-10)

  A new class of dirhodium carboxylate catalysts have been designed and synthesized from 2-fenchyloxy or 2-menthyloxy arylacetic acids which display excellent enantioselectivity across a range of transformations of ...

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