• Sodium aspirin salts: crystallization and characterization 

  Búdová, Miroslava; Skořepová, Eliška; Jan, Čejka (American Chemical Society, 2018-07-09)

  Acetylsalicylic acid (trade name aspirin) is a well-known drug with antipyretic and analgesic effects. Mixtures that benefit from better solubility of its sodium salt have been sold for almost 90 years. Currently, several ...
• Tracking cocrystallization of active pharmaceutical ingredients with Bbenzoic acid coformer using Broadband Acoustic resonance Dissolution Spectroscopy (BARDS) 

  Kent, Christopher; Rao Khandavilli, Udaya B. Rao; Alfarsi, Anas; Hanna-Brown, Melissa; McSweeney, Seán; Krüse, Jacob; Lawrence, Simon E.; Fitzpatrick, Dara (American Chemical Society, 2018-09-18)

  This study investigates the use of Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) as a detection method for the formation of cocrystals. BARDS is a novel approach that uses reproducible changes in the ...
• Isoquinolinequinone N-oxides as anticancer agents effective against drug resistant cell lines 

  Kruschel, Ryan D.; Buzid, Alyah; Khandavilli, Udaya Bhaskara Rao; Lawrence, Simon E.; Glennon, Jeremy D.; McCarthy, Florence O. (Royal Society of Chemistry, 2019-12-18)

  The isoquinolinequinone (IQQ) pharmacophore is a privileged framework in known cytotoxic natural product families, caulibugulones and mansouramycins. Exploiting both families as a chemical starting point, we report on the ...
• Tracking compression changes in an aqueous electrolyte for real-Time H2 and O2 gas evolution quantification during total water splitting using BARDS 

  Kang, Aaron; Alkhraije, Alanood; McSweeney, Sean; Alfarsi, Anas; Ahmed, Rizwan; Krüse, Jacob; O'Dwyer, Colm; Fitzpatrick, Dara (American Chemical Society, 2020-01)

  Hydrogen fuel cell technology has the potential for integration with renewable energy sources to produce electricity without the need for fossil fuels. Efforts are being made in producing cheap and effective electrodes ...
• The emergence of Pd-mediated reversible oxidative addition in cross coupling, carbohalogenation and carbonylation reactions 

  Jones, David J.; Lautens, Mark; McGlacken, Gerard P. (Springer Nature, 2019-10-07)

  Exploiting the reversibility of chemical processes is a long-standing tactic of organic chemists, and permeates most areas of the discipline. The notion that oxidative addition of Pd(0) to Ar–X bonds can be considered an ...

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