• Scale-up and optimization of a continuous flow synthesis of an α-thio-βchloroacrylamide 

  Dennehy, Olga C.; Lynch, Denis; Collins, Stuart G.; Maguire, Anita R.; Moynihan, Humphrey A. (American Chemical Society, 2020-05-19)

  Use of continuous flow processing to undertake a multistep chlorination cascade has been achieved with effective inline work-up and end-of-line crystallization in batch leading to isolation of α-thio-β-chloroacrylamide Z-3 ...
• Organolithium bases in flow chemistry: a review 

  Power, Mark; Alcock, Emma; McGlacken, Gerard P. (American Chemical Society, 2020-04-30)

  Flow chemistry is a continually emerging and ever-growing area of synthetic organic chemistry. It provides an orthogonal approach to traditional batch chemistry, oftentimes allowing for more efficient routes to desired ...
• A robust methodology for the synthesis of phosphorothioates, phosphinothioates and phosphonothioates 

  Jones, David J.; O'Leary, Eileen M.; O'Sullivan, Timothy P. (Wiley, 2020-03-04)

  A robust methodology for the synthesis of phosphorothioates, phosphinothioates and phosphonothioates, including those bearing low molecular weight S‐alkyl side‐chains, is presented. Application of the “caesium effect” in ...
• The sound of tablets during coating erosion, disintegration, deaggregation and dissolution 

  O'Mahoney, Niamh; Keating, John J.; McSweeney, Seán; Hill, Sam; Lawrence, Simon E.; Fitzpatrick, Dara (Elsevier, 2020-03-09)

  This research aims to address a gap in our understanding of the mechanisms by which pharmaceutical tablets achieve highly reproducible and predictable drug release. The present industrial and regulatory practice is centred ...
• Sodium aspirin salts: crystallization and characterization 

  Búdová, Miroslava; Skořepová, Eliška; Jan, Čejka (American Chemical Society, 2018-07-09)

  Acetylsalicylic acid (trade name aspirin) is a well-known drug with antipyretic and analgesic effects. Mixtures that benefit from better solubility of its sodium salt have been sold for almost 90 years. Currently, several ...

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