• Will they co-crystallize? 

  Wicker, Jerome G. P.; Crowley, Lorraine M.; Robshaw, Oliver; Little, Edmund J.; Stokes, Stephen P.; Cooper, Richard I.; Lawrence, Simon E. (Royal Society of Chemistry, 2017)

  A data-driven approach to predicting co-crystal formation reduces the number of experiments required to successfully produce new co-crystals. A machine learning algorithm trained on an in-house set of co-crystallization ...
• Determination of composition distributions of multi-particle crystalline samples by sequential dissolution with concomitant particle sizing and solution analysis 

  Moynihan, Humphrey A.; Armstrong, Declan (Royal Society of Chemistry, 2018-04)

  Impurities arise in the production of molecular pharmaceutical and fine chemical products and are often addressed by crystallisation. However, impurities are not always adequately removed by crystallisations and in some ...
• Cocrystals and a salt of the bioactive flavonoid: naringenin 

  Khandavilli, Udaya Bhaskara Rao; Skořepová, Eliška; Sinha, Abhijeet S.; Bhogala, Balakrishna R.; Maguire, Nuala M.; Maguire, Anita R.; Lawrence, Simon E. (American Chemical Society, 2018-07-03)

  Cocrystallization studies on Naringenin with 27 coformers have led to the formation of five new solid forms: a piperazinium salt (PIP+-NR-) and four cocrystals with the coformers flavone (FLV), 4-hydroxypyridine (4-HP), ...
• Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS): a novel approach to investigate the wettability of pharmaceutical powder blends 

  Peddapatla, Raghhu V. G.; Ahmed, M. Rizwan; Blackshields, Caroline A.; Sousa-Gallagher, Maria J.; McSweeney, Sean; Kruse, Jacob; Crean, Abina M.; Fitzpatrick, Dara (American Chemical Society, 2017-09-19)

  The ability of Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) to assess the wettability of powder blends is investigated. BARDS is a novel analytical technology developed based on the change in acoustic ...
• Synthesis of symmetrically and unsymmetrically substituted S,S-dialkyl phosphonodithioates 

  Jones, David J.; O'Leary, Eileen M.; O'Sullivan, Timothy P. (Elsevier, 2017-09-22)

  Herein, we report the synthesis of a range of S,S-dialkyl phosphonodithioates. Symmetrically substituted analogues were readily prepared from the corresponding phosphonic dichlorides in good to moderate yields, while ...

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