• Structure-activity relationships of furanones, dihydropyrrolones and thiophenones as potential quorum sensing inhibitors 

  Lyons, Thérèse; Gahan, Cormac G. M.; O'Sullivan, Timothy P. (Newlands Press, 2020-10-23)

  Since their initial isolation from the marine alga Delisea pulchra, bromofuranones have been investigated as potential inhibitors of quorum sensing (QS) in various bacterial strains. QS is an important mechanism by which ...
• Synthesis and biological evaluation of novel thionucleosides 

  O'Donovan, Fiona P.; O'Leary, Eileen M.; O'Sullivan, Timothy P. (Bentham Science Publishers, 2020-11-01)

  The search for novel nucleosides has been a major research focus in medicinal chemistry for several decades, particularly given their proven track record in the treatment of viral infections and cancer. As bioisosteres of ...
• Exploiting the continuous in situ generation of mesyl azide for use in a telescoped process 

  O'Mahony, Rosella M.; Lynch, Denis; Hayes, Hannah L. D.; Ní Thuama, Eilís; Donnellan, Philip; Jones, Roderick C.; Glennon, Brian; Collins, Stuart G.; Maguire, Anita R. (Wiley, 2017-08-21)

  The hazardous diazo transfer reagent mesyl azide has been safely generated and used in situ for continuous diazo transfer as part of an integrated synthetic process with an embedded safety quench. Diazo transfer to β‐keto ...
• Localized partitioning of enantiomers in solid samples of sulfoxides: importance of sampling method in determination of enantiopurity 

  Flynn, Aaran J.; Ford, Alan; Maguire, Anita R. (American Chemical Society, 2020-07-02)

  Localized partitioning of amorphous enantioenriched aryl benzyl sulfoxides in the solid state can lead to substantial variation in enantiopurities, even for sulfoxides which do not show detectable levels of self-disproportionation ...
• Taming tosyl azide: the development of a scalable continuous diazo transfer process 

  Deadman, Benjamin J.; O'Mahony, Rosella M.; Lynch, Denis; Crowley, Daniel C.; Collins, Stuart G.; Maguire, Anita R. (Royal Society of Chemistry, 2016-03-01)

  Heat and shock sensitive tosyl azide was generated and used on demand in a telescoped diazo transfer process. Small quantities of tosyl azide were accessed in a 'one pot' batch procedure using shelf stable, readily available ...

View more