Investigation of additive effects in enantioselective copper-catalysed C-H insertion and aromatic addition reactions of α-diazocarbonyl compounds

Slattery, Catherine N.; Clarke, Leslie-Ann; O'Neill, Shane T.; Ring, Aoife; Ford, Alan; Maguire, Anita R.

Investigation of additive effects in enantioselective copper-catalysed C-H insertion and aromatic addition reactions of α-diazocarbonyl compounds

Files

AM_InvestigationAV2012.pdf(103 KB)

Accepted Version

Date

2012-01

Authors

Slattery, Catherine N.

Clarke, Leslie-Ann

O'Neill, Shane T.

Ring, Aoife

Ford, Alan

Maguire, Anita R.

Publisher

Georg Thieme Verlag

Published Version

10.1055/s-0031-1290598

Abstract

Significant enhancements in enantioselectivities and reaction efficiencies in asymmetric copper-catalysed C-H insertion and aromatic addition reactions of α-diazocarbonyl compounds in the presence of various group I salts are reported. For the first time in carbenoid chemistry, evidence for the critical role of the metal cation is described.

Keywords

C-H insertion , Buchner reaction , Diazocarbonyl , Copper catalysis , Bis(oxazoline) ligands , Carbene insertion , Bonds , Complexes

Citation

Slattery, C. N., Clarke, L. A., O'Neill, S., Ring, A., Ford, A. and Maguire, A. R. (2012) 'Investigation of additive effects in enantioselective copper-catalysed C-H insertion and aromatic addition reactions of α-diazocarbonyl compounds', Synlett, 23(5), pp. 765-767. DOI: 10.1055/s-0031-1290598