Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate

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dc.contributor.author Slattery, Catherine N.
dc.contributor.author Deasy, Rebecca E.
dc.contributor.author Maguire, Anita R.
dc.contributor.author Kopach, Michael E.
dc.contributor.author Singh, Utpal K.
dc.contributor.author Argentine, Mark D.
dc.contributor.author Trankle, William G.
dc.contributor.author Scherer, Roger B.
dc.contributor.author Moynihan, Humphrey A.
dc.date.accessioned 2016-08-17T08:54:20Z
dc.date.available 2016-08-17T08:54:20Z
dc.date.issued 2013-05-30
dc.identifier.citation Slattery, C. N., Deasy, R. E., Maguire, A. R., Kopach, M. E., Singh, U. K., Argentine, M. D., Trankle, W. G., Scherer, R. B. and Moynihan, H. A. (2013) 'Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate', Journal of Organic Chemistry, 78(12), pp. 5955-5963. http://dx.doi.org/10.1021/jo400647t en
dc.identifier.volume 78 en
dc.identifier.issued 12 en
dc.identifier.startpage 5955 en
dc.identifier.endpage 5963 en
dc.identifier.issn 0022-3263
dc.identifier.uri http://hdl.handle.net/10468/2998
dc.identifier.doi 10.1021/jo400647t
dc.description.abstract An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup. en
dc.description.sponsorship Enterprise Ireland (financial support of C.N.S. and R.E.D.) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Chemical Society en
dc.rights © 2013 American Chemical Society. This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/jo400647t en
dc.subject Efficient process en
dc.subject Formylation en
dc.subject Hydride reduction en
dc.subject Hydroxymethylation en
dc.subject Pharmaceutical intermediates en
dc.subject Scale-up en
dc.subject Synthetic approach en
dc.subject Hydroxymethyl groups en
dc.title Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Anita Maguire, Vice President For Research, University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.maguire@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2016-08-16T15:58:58Z
dc.description.version Submitted Version en
dc.internal.rssid 264353326
dc.contributor.funder Enterprise Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Organic Chemistry en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress a.maguire@ucc.ie en


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