Development of stabilized vaccines with needle-free devices for targeted skin immunization
Moore, Anne C.
Crean, Abina M.
Russell Publishing Limited
Vaccination represents the primary public health measure to combat infectious diseases. However, limitations of cold-chain storage, vaccine wastage, hazardous sharps-waste and the requirements for trained personnel add significant and unsustainable financial and logistic costs to immunisation programmes. Developments of needle-free methods should aim to overcome these logistics issues from the very start of the vaccine production process. Dermal vaccine administration using microneedle-based devices promises to be one such needle-free method that addresses all of these issues. Methods of stabilisation of vaccines onto or incorporated into microneedles should be developed to permit seamless transition and cost-effectiveness from vaccine bulk-up to final product. This review examines recent developments in microneedle technology and highlights the current challenges to translate this technology into practice.
Vaccine delivery , Microneedle
MOORE, A. C., CREAN, A. M. & O'MAHONY, C. 2010. Development of stabilized vaccines with needle-free devices for targeted skin immunization. European Pharmaceutical Review, 15(6), pp. 56-60.
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