Gene × environment interactions in schizophrenia: evidence from genetic mouse models

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Gene × environment interactions in schizophrenia: evidence from genetic mouse models

Moran, Paula M.; Stokes, Jennifer; Marr, Julia; Bock, Gavin; Desbonnet, Lieve; Waddington, John; O'Tuathaigh, Colm M. P.
Date: 2016-08-21
Copyright: © 2016 Paula Moran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright information: https://creativecommons.org/licenses/by/4.0/
Citation: Moran, P., Stokes, J., Marr, J., Bock, G., Desbonnet, L., Waddington, J. and O’Tuathaigh, C. (2016) Gene × environment interactions in schizophrenia: evidence from genetic mouse models. Neural Plasticity, 2173748 (23pp). doi: 10.1155/2016/2173748.
Published Version: 10.1155/2016/2173748

Abstract:

The study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia. It has also increased our understanding of the role of susceptibility genes in the disorder and is an important consideration as we seek to translate genetic advances into novel antipsychotic treatment targets. This review summarises data arising from research involving the modelling of gene × environment interactions in schizophrenia using preclinical genetic models. Evidence for synergistic effects on the expression of schizophrenia-relevant endophenotypes will be discussed. It is proposed that valid and multifactorial preclinical models are important tools for identifying critical areas, as well as underlying mechanisms, of convergence of genetic and environmental risk factors, and their interaction in schizophrenia.

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© 2016 Paula Moran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as © 2016 Paula Moran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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