Gene × environment interactions in schizophrenia: evidence from genetic mouse models

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dc.contributor.authorMoran, Paula M.
dc.contributor.authorStokes, Jennifer
dc.contributor.authorMarr, Julia
dc.contributor.authorBock, Gavin
dc.contributor.authorDesbonnet, Lieve
dc.contributor.authorWaddington, John
dc.contributor.authorO'Tuathaigh, Colm M. P.
dc.date.accessioned2016-10-05T15:45:09Z
dc.date.available2016-10-05T15:45:09Z
dc.date.issued2016-08-21
dc.description.abstractThe study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia. It has also increased our understanding of the role of susceptibility genes in the disorder and is an important consideration as we seek to translate genetic advances into novel antipsychotic treatment targets. This review summarises data arising from research involving the modelling of gene × environment interactions in schizophrenia using preclinical genetic models. Evidence for synergistic effects on the expression of schizophrenia-relevant endophenotypes will be discussed. It is proposed that valid and multifactorial preclinical models are important tools for identifying critical areas, as well as underlying mechanisms, of convergence of genetic and environmental risk factors, and their interaction in schizophrenia.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMoran, P., Stokes, J., Marr, J., Bock, G., Desbonnet, L., Waddington, J. and O’Tuathaigh, C. (2016) Gene × environment interactions in schizophrenia: evidence from genetic mouse models. Neural Plasticity, 2173748 (23pp). doi: 10.1155/2016/2173748.en
dc.identifier.doi10.1155/2016/2173748
dc.identifier.endpage2173748-23en
dc.identifier.issn2090-5904
dc.identifier.journaltitleNeural Plasticityen
dc.identifier.startpage2173748-1en
dc.identifier.urihttps://hdl.handle.net/10468/3161
dc.language.isoenen
dc.publisherHindawi Publishingen
dc.rights© 2016 Paula Moran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectSchizophreniaen
dc.subjectEndophenotypesen
dc.subjectEtiopathologic basisen
dc.subjectEpistatic interactionsen
dc.subjectSusceptibility genesen
dc.subjectEnvironment interactionsen
dc.subjectSchizophrenia-relevant endophenotypesen
dc.subjectGenetic risk factorsen
dc.subjectEnvironmental risk factorsen
dc.titleGene × environment interactions in schizophrenia: evidence from genetic mouse modelsen
dc.typeArticle (peer-reviewed)en
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