The role of area-level deprivation and gender in participation in population-based faecal immunochemical test (FIT) colorectal cancer screening

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dc.contributor.author Clarke, Nicholas
dc.contributor.author McNamara, Deirdre
dc.contributor.author Kearney, Patricia M.
dc.contributor.author O'Morain, Colm A.
dc.contributor.author Shearer, Nikki
dc.contributor.author Sharp, Linda
dc.date.accessioned 2016-11-17T14:31:13Z
dc.date.available 2016-11-17T14:31:13Z
dc.date.issued 2016-10-18
dc.identifier.citation Clarke, N., D. McNamara, P. M. Kearney, C. A. O'Morain, N. Shearer and L. Sharp (2016) ‘The role of area-level deprivation and gender in participation in population-based faecal immunochemical test (FIT) colorectal cancer screening’, Preventive Medicine 93 pp. 198-203. doi: 10.1016/j.ypmed.2016.10.012 en
dc.identifier.volume 93 en
dc.identifier.startpage 198 en
dc.identifier.endpage 203 en
dc.identifier.issn 0091-7435
dc.identifier.uri http://hdl.handle.net/10468/3284
dc.identifier.doi 10.1016/j.ypmed.2016.10.012
dc.description.abstract This study aimed to investigate the effects of sex and deprivation on participation in a population-based faecal immunochemical test (FIT) colorectal cancer screening programme. The study population included 9785 individuals invited to participate in two rounds of a population-based biennial FIT-based screening programme, in a relatively deprived area of Dublin, Ireland. Explanatory variables included in the analysis were sex, deprivation category of area of residence and age (at end of screening). The primary outcome variable modelled was participation status in both rounds combined (with “participation” defined as having taken part in either or both rounds of screening). Poisson regression with a log link and robust error variance was used to estimate relative risks (RR) for participation. As a sensitivity analysis, data were stratified by screening round. In both the univariable and multivariable models deprivation was strongly associated with participation. Increasing affluence was associated with higher participation; participation was 26% higher in people resident in the most affluent compared to the most deprived areas (multivariable RR = 1.26: 95% CI 1.21–1.30). Participation was significantly lower in males (multivariable RR = 0.96: 95%CI 0.95–0.97) and generally increased with increasing age (trend per age group, multivariable RR = 1.02: 95%CI, 1.01–1.02). No significant interactions between the explanatory variables were found. The effects of deprivation and sex were similar by screening round. Deprivation and male gender are independently associated with lower uptake of population-based FIT colorectal cancer screening, even in a relatively deprived setting. Development of evidence-based interventions to increase uptake in these disadvantaged groups is urgently required. en
dc.description.sponsorship Irish Cancer Society (Grant no: CRS11CLA) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights © 2016 Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Colorectal en
dc.subject Cancer en
dc.subject Screening en
dc.subject Faecal Immunochemical Test en
dc.subject FIT en
dc.subject Participation en
dc.subject Deprivation en
dc.subject Gender en
dc.title The role of area-level deprivation and gender in participation in population-based faecal immunochemical test (FIT) colorectal cancer screening en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Nicholas Clarke, Epidemiology and Public Health, University College Cork, Cork, Ireland. T +21 353 490 3000. E: nicholas.clarke@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by the request of the publisher. en
dc.check.date 2017-10-18
dc.description.version Accepted Version en
dc.contributor.funder Irish Cancer Society en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Preventive Medicine en
dc.internal.copyrightchecked !!CORA!! en
dc.internal.IRISemailaddress nicholas.clarke@ucc.ie en


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© 2016 Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ Except where otherwise noted, this item's license is described as © 2016 Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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