• Sphingosine 1-phosphate (S1P) signalling: role in bone biology and potential therapeutic target for bone repair 

  Sartawi, Ziad; Schipani, Ernestina; Ryan, Katie B.; Waeber, Christian (Elsevier Ltd, 2017-08-30)

  The lipid mediator sphingosine 1-phosphate (S1P) affects cellular functions in most systems. Interest in its therapeutic potential has increased following the discovery of its G protein-coupled receptors and the recent ...
• Parental knowledge, attitudes and beliefs on fever: a cross-sectional study in Ireland 

  Kelly, Maria; Sahm, Laura J.; Shiely, Frances; O’Sullivan, Ronan; de Bont, Eefje G.; Mc Gillicuddy, Aoife; Herlihy, Roisin; Dahly, Darren; McCarthy, Suzanne (BMJ Publishing Group, 2017)

  Objectives: Fever is a common symptom of mostly benign illness in young children, yet concerning for parents. The aim of this study was to describe parental knowledge, attitudes and beliefs regarding fever in children aged ...
• The influence of process parameters on the physical characteristics of ceramic microneedles, evaluated using a factorial design 

  Carracedo-Taboada, Marta; O'Sullivan, Kathleen; McAuliffe, Michael A. P.; Vucen, Sonja; O'Sullivan, Caroline (Elsevier, 2017-10-05)

  The paper presents the application of the factorial Design of Experiments (DoE) to evaluate the influence of process parameters on the physical characteristics of ceramic microneedles (CMN). In this study, an understanding ...
• Folate-targeted amphiphilic cyclodextrin nanoparticles incorporating a fusogenic peptide deliver therapeutic siRNA and inhibit the invasive capacity of 3D prostate cancer tumours 

  Evans, James C.; Malhotra, Meenakshi; Sweeney, Katrina; Darcy, Raphael; Nelson, Colleen C.; Hollier, Brett G.; O'Driscoll, Caitríona M. (Elsevier, 2017-09-13)

  The main barrier to the development of an effective RNA interference (RNAi) therapy is the lack of a suitable delivery vector. Modified cyclodextrins have emerged in recent years for the delivery of siRNA. In the present ...
• Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain 

  Song, Dan-Dan; Zhang, Tong-Tong; Chen, Jia-Li; Xia, Yun-Fei; Qin, Zheng-Hong; Waeber, Christian; Sheng, Rui (Nature Publishing Group, 2017)

  Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in ...

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