• Development of anisamide-targeted PEGylated gold nanorods to deliver epirubicin for chemo-photothermal therapy in tumour-bearing mice 

  Wang, Limei; Pei, Jin; Cong, Zhongcheng; Zou, Yifang; Sun, Tianmeng; Davitt, Fionán; Garcia-Gil, Adrià; Holmes, Justin D.; O'Driscoll, Caitríona M.; Rahme, Kamil; Guo, Jianfeng (Dove Press, 2019-03-08)

  Background: Gold nanorods (AuNRs), due to the optical and electronic properties namely the surface plasma resonance, have been developed to achieve the light-mediated photothermal therapy (PTT) for cancer. However, PTT ...
• Short-term consumption of a high-fat diet increases host susceptibility to Listeria monocytogenes infection 

  Las Heras, Vanessa; Clooney, Adam G.; Ryan, Feargal J.; Cabrera-Rubio, Raul; Casey, Pat G.; Hueston, Cara M.; Pinheiro, Jorge; Rudkin, Justine K.; Melgar, Silvia; Cotter, Paul D.; Hill, Colin; Gahan, Cormac G. M. (BioMed Central, 2019)

  A westernized diet comprising a high caloric intake from animal fats is known to influence the development of pathological inflammatory conditions. However, there has been relatively little focus upon the implications of ...
• Cost minimization analysis of intravenous or subcutaneous trastuzumab treatment in patients with HER2-positive breast cancer in Ireland 

  O'Brien, Gary L.; O'Mahony, Cian; Cooke, Katie; Kinneally, Ada; Sinnott, Sarah-Jo; Walshe, Valerie; Mulcahy, Mark; Byrne, Stephen (Elsevier Inc., 2019-02-06)

  Background: Two large acute Irish University teaching hospitals changed the manner in which they treated human epidermal growth factor receptor (HER)2-positive breast cancer patients by implementing the administration of ...
• The PEARRL reviews - innovative drug development strategies tailored to facilitate earlier access to new oral medicines [Editorial] 

  Griffin, Brendan T.; Dressman, Jennifer B. (John Wiley & Sons, Inc., 2019-03-03)
• Anisamide-targeted PEGylated gold nanoparticles designed to target prostate cancer mediate: enhanced systemic exposure of siRNA, tumour growth suppression and a synergistic therapeutic response in combination with paclitaxel in mice 

  Luan, Xue; Rahme, Kamil; Cong, Zhongcheng; Wang, Limei; Zou, Yifang; He, Yan; Yang, Hao; Holmes, Justin D.; O'Driscoll, Caitríona M.; Guo, Jianfeng (Elsevier, 2019-02-16)

  Small interfering RNA (siRNA) has recently illustrated therapeutic potential for malignant disorders. However, the clinical application of siRNA-based therapeutics is significantly retarded by the paucity of successful ...

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