• Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS): a rapid test for enteric coating thickness and integrity of controlled release pellet formulations 

  Dillon, Amy; Alfarsi, Anas; McSweeney, Seán; Krüse, Jacob; Griffin, Brendan; Devine, Ken; Sherry, Patricia; Henken, Stephan; Fitzpatrick, Stephen; Fitzpatrick, Dara (Elsevier B.V., 2018-04-12)

  There are no rapid dissolution based tests for determining coating thickness, integrity and drug concentration in controlled release pellets either during production or post-production. The manufacture of pellets requires ...
• The pig as a pre-clinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms - a PEARRL review 

  Henze, Laura J.; Koehl, Niklas J.; O'Shea, Joseph P.; Kostewicz Edmund; Holm, Rene; Griffin, Brendan T. (Wiley, 2018-04-10)

  Objectives: In pharmaceutical drug development, preclinical tests in animal models are essential to demonstrate whether the new drug is orally bioavailable and to gain a first insight into in vivo pharmacokinetic parameters ...
• Substrate and catalyst effects in the enantioselective copper catalysed C–H insertion reactions of α-diazo-β-oxo sulfones 

  Maguire, Anita R.; Shiely, Amy; Clarke, Leslie Ann; Flynn, Chris; Buckley, Aoife; Ford, Alan; Lawrence, Simon E. (John Wiley & Sons, Inc., 2018-03-23)

  Excellent enantioselectivities of up to 98% ee are achieved employing the copper‐bis(oxazoline)‐NaBARF catalyst system in the C‐H insertion reactions of α‐diazo‐β‐oxo sulfones. The influence of variation of the bis(oxazoline) ...
• Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide 

  Henze, Laura J.; Griffin, Brendan T.; Christiansen, Martin; Bundgaard, Christoffer; Langguth, Peter; Holm, Rene (Elsevier, 2018-03-17)

  The present study investigated the gastric emptying rate in Göttingen minipigs pre- and post-prandial and evaluated the effect of metoclopramide on the same parameter, using paracetamol as an absorption marker. The ...
• Copper mediated, heterogeneous, enantioselective intramolecular Buchner reactions of a-diazoketones using continuous flow processing 

  Crowley, Daniel C.; Lynch, Denis; Maguire, Anita R. (American Chemical Society, 2018-03-15)

  Enantioselective intramolecular Buchner reactions of α-diazoketones can be effected using heterogeneous copper−bis(oxazoline) catalysts in batch or using continuous flow processing in up to 83% ee. The catalyst can be ...

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