• Synthesis of novel quinine analogs and evaluation of their effects on Trypanosoma cruzi 

  Ceole, Ligia F.; Gandhi, Hirenkumar; Villamizar, Luz H.; Soares, Maurilio J.; O'Sullivan, Timothy P. (Future Science: Newlands Press, 2018-02)

  Aim: Chagas disease is a tropical disease caused by the hemoflagellate protozoan Trypanosoma cruzi. There is no vaccine for Chagas disease and available drugs (e.g., benznidazole) are effective only during the acute phase, ...
• Asymmetric peroxidation of α,β-unsaturated aldehydes under diarylprolinol ether catalysis 

  O'Reilly, Kate; Gupta, Manoj K.; Gandhi, Hirenkumar; Kumar, Vydyula P.; O'Sullivan, Timothy P. (Bentham Science Publishers, 2017)

  Background: Chiral peroxides, many of which are biologically active, are an attractive target in organic synthesis. Organocatalysts have been used for some time in the asymmetric epoxidation of α,β- unsaturated carbonyls. ...
• Preparation of γ,δ-unsaturated-β-ketoesters: Lewis acid-catalysed CH insertion of ethyl diazoacetate into α,β-unsaturated aldehydes 

  Gandhi, Hirenkumar; O'Sullivan, Timothy P. (Elsevier, 2017-07-29)

  The synthesis of γ,δ-unsaturated-β-keto esters was achieved by the Lewis acid-catalysed direct CH insertion of an α-diazoester into various α,β-substituted-unsaturated aldehydes. CH insertion of ethyl diazoacetate into ...
• Regulation of biosimilar medicines and current perspectives on interchangeability and policy 

  O'Callaghan, John; Barry, Sean P.; Bermingham, Margaret; Morris, J. Michael; Griffin, Brendan T. (Springer Nature Switzerland AG, 2018-09-05)

  Competition arising from the increasing availability of biosimilar medicines has resulted in healthcare savings and has provided greater patient access to high cost therapeutics in Europe. The biosimilar market in the USA ...
• Exploring antipsychotic prescribing behaviors for nursing home residents with dementia: a qualitative study 

  Walsh, Kieran A.; Sinnott, Carol; Fleming, Aoife; Mc Sharry, Jenny; Byrne, Stephen; Browne, John; Timmons, Suzanne (Elsevier, 2018-11)

  Objectives: Caution is advised when prescribing antipsychotics to people with dementia. This study explored the determinants of appropriate, evidence-based antipsychotic prescribing behaviors for nursing home residents ...

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