• Short chain fatty acids: microbial metabolites for gut-brain axis signalling 

  O'Riordan, Kenneth J.; Collins, Michael K.; Moloney, Gerard M.; Knox, Emily G.; Aburto, Maria Rodriguez; Fulling, Christine; Morley, Shane J.; Clarke, Gerard; Schellekens, Harriët; Cryan, John F. (Elsevier B. V., 2022-04)

  The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the ...
• Antimicrobial use and antimicrobial resistance in Enterobacterales and Enterococcus faecium: a time series analysis 

  O'Riordan, Frank; Shiely, Frances; Byrne, Stephen; O'Brien, Deirdre; Ronayne, Aoife; Fleming, Aoife (Elsevier, 2022-01-01)

  Background: Irish and European antimicrobial resistance (AMR) surveillance data have highlighted increasing AMR in Enterobacterales and vancomycin resistance in Enterococcus faecium (VRE). Antimicrobial consumption (AC) ...
• Genome mining and characterisation of a novel transaminase with remote stereoselectivity 

  Gavin, Declan P.; Reen, F. Jerry; Rocha-Martin, J.; Abreu-Castilla, I.; Woods, David F.; Foley, Aoife M.; Sanchez-Murcia, P. A.; Schwarz, Maria; O'Neill, P.; Maguire, Anita R.; O'Gara, Fergal (Springer Nature Switzerland AG, 2019-12-30)

  Microbial enzymes from pristine niches can potentially deliver disruptive opportunities in synthetic routes to Active Pharmaceutical Ingredients and intermediates in the Pharmaceutical Industry. Advances in green chemistry ...
• Gut microbiota-drug interactions in cancer pharmacotherapies: implications for efficacy and adverse effects 

  Leigh, Sarah-Jane; Lynch, Caoimhe M. K.; Healey Bird, Brian R.; Griffin, Brendan T.; Cryan, John F.; Clarke, Gerard (Taylor & Francis, 2022-02-17)

  Introduction: The gut microbiota is involved in host physiology and health. Reciprocal microbiota-drug interactions are increasingly recognized as underlying some individual differences in therapy response and adverse ...
• Gastrointestinal diseases and their impact on drug solubility: Crohn's disease 

  Effinger, Angela; O'Driscoll, Caitriona M.; McAllister, Mark; Fotaki, Nikoletta (Elsevier B.V., 2020-07-11)

  In order to investigate differences in drug solubilisation and dissolution in luminal fluids of Crohn's disease (CD) patients and healthy subjects, biorelevant media representative of CD patients were developed using ...

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