• Toward the establishment of a standardized pre-clinical porcine model to predict food effects - case studies on Fenofibrate and Paracetamol 

  Henze, Laura J.; Koehl, Niklas J.; O'Shea, Joseph P.; Holm, René; Vertzoni, Maria; Griffin, Brendan T. (Elsevier, 2019-05-28)

  A preclinical porcine model that reliably predicts human food effect of fenofibrate was developed. Fenofibrate was administered to pigs as model compound with a positive food effect. Two different types of fed conditions ...
• An improved synthesis of adefovir and related analogues 

  Jones, David J.; O'Leary, Eileen M.; O'Sullivan, Timothy P. (Beilstein-Institut, 2019-03-29)

  An improved synthesis of the antiviral drug adefovir is presented. Problems associated with current routes to adefovir include capricious yields and a reliance on problematic reagents and solvents, such as magnesium ...
• Desymmetrization by asymmetric copper-catalyzed intramolecular C–H insertion reactions of α-diazo-β-oxosulfones 

  Brouder, Thomas A.; Slattery, Catherine N.; Ford, Alan; Khandavilli, Udaya Bhaskara Rao; Skořepová, Eliška; Eccles, Kevin S.; Lusi, Matteo; Lawrence, Simon E.; Maguire, Anita R. (American Chemical Society, ACS, 2019-03-04)

  Effective desymmetrization in copper-catalyzed intramolecular C–H insertion reactions of α-diazo-β-oxosulfones in the formation of fused thiopyran dioxides is described for the first time. The use of a copper–bis(oxazoline)–NaBARF ...
• A thematic analysis of pharmacy students' experiences of the undergraduate pharmacy degree in Ireland and the role of mindfulness 

  O'Driscoll, Michelle; Byrne, Stephen; Kelly, Maria; Lambert, Sharon; Sahm, Laura J. (American Association of Colleges of Pharmacy (AACP), 2019)

  Objective: To determine pharmacy students' experiences of stress as part of the current pharmacy degree, and to explore the potential of incorporating the principles of mindfulness into course work in the undergraduate ...
• Development of anisamide-targeted PEGylated gold nanorods to deliver epirubicin for chemo-photothermal therapy in tumour-bearing mice 

  Wang, Limei; Pei, Jin; Cong, Zhongcheng; Zou, Yifang; Sun, Tianmeng; Davitt, Fionán; Garcia-Gil, Adrià; Holmes, Justin D.; O'Driscoll, Caitríona M.; Rahme, Kamil; Guo, Jianfeng (Dove Press, 2019-03-08)

  Background: Gold nanorods (AuNRs), due to the optical and electronic properties namely the surface plasma resonance, have been developed to achieve the light-mediated photothermal therapy (PTT) for cancer. However, PTT ...

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