• Preeclampsia and neurodevelopmental outcomes: Potential pathogenic roles for inflammation and oxidative stress? 

  Barron, Aaron; McCarthy, Cathal; O'Keeffe, Gerard W. (Springer Nature Switzerland AG, 2021-01-25)

  Preeclampsia (PE) is a common and serious hypertensive disorder of pregnancy that occurs in approximately 3â 5% of first-time pregnancies and is a well-known leading cause of maternal and neonatal mortality and morbidity. ...
• Exploring the impact of surfactant type and digestion: Highly digestible surfactants improve oral bioavailability of nilotinib 

  Koehl, Niklas J.; Holm, René; Kuentz, Martin; Jannin, Vincent; Griffin, Brendan T. (ACS Publications, 2020-07-10)

  The scientific rationale for selection of the surfactant type during oral formulation development requires an in-depth understanding of the interplay between surfactant characteristics and biopharmaceutical factors. ...
• The effect of sphingosine‐1‐phosphate on the endothelial glycocalyx during ischemia‐reperfusion injury in the isolated rat heart 

  Araibi, Hala; van der Merwe, Elizabeth; Gwanyanya, Asfree; Kelly‐Laubscher, Roisin (John Wiley & Sons, Inc., 2020-02-03)

  Objective: Sphingosine‐1‐phosphate is a natural metabolite that is cardioprotective, but its effects on endothelial glycocalyx damage during ischemia‐reperfusion are unknown. Therefore, we investigated the effect of ...
• Bone regenerative potential of the selective sphingosine 1-phosphate receptor modulator siponimod: In vitro characterisation using osteoblast and endothelial cells 

  Sartawi, Zaid; Ryan, Katie B.; Waeber, Christian (Elsevier B.V., 2020-06-10)

  The repair of critical bone defects remains a significant therapeutic challenge. While the implantation of drug-eluting scaffolds is an option, a drug with the optimal pharmacological properties has not yet been identified. ...
• Investigating mitochondrial dysfunction in gestational diabetes mellitus and elucidating if BMI is a causative mediator 

  McElwain, Colm; McCarthy, Cathal M. (Elsevier B.V., 2020-05-21)

  Objective: Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance which is diagnosed during pregnancy and poses considerable health risks for mother and child. Maternal body mass index (BMI) ...

View more