• Discovery and pharmacological characterisation of angiotensin-(1-7) receptors and identification of their importance in diabetes mellitus 

  Tetzner, Anja (University College Cork, 2018)

  The renin-angiotensin system (RAS) is known to be the main regulator of blood pressure and fluid balance. Within the RAS, angiotensin (Ang)-(1-7) is known to have cardiovascular protective effects. It represents the opponent ...
• A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: does maternal inflammation play a role? 

  Maher, Gillian M.; McCarthy, Fergus P.; McCarthy, Cathal M.; Kenny, Louise C.; Kearney, Patricia M.; Khashan, Ali S.; O'Keeffe, Gerard W. (Elsevier Ltd., 2018-11-02)

  Pre-eclampsia is a leading cause of maternal death and maternal and perinatal morbidity. Whilst the clinical manifestations of pre-eclampsia often occur in late pregnancy, the molecular events leading into the onset of ...
• Bioaccessibility and bioavailability of a marine-derived multimineral, Aquamin-Magnesium 

  Felice, Valeria D.; O'Gorman, Denise M.; O'Brien, Nora M.; Hyland, Niall P. (MDPI AG, 2018)

  Introduction: Magnesium is an essential mineral involved in a range of key biochemical pathways. Several magnesium supplements are present on the market and their degree of bioavailability differs depending on the form of ...
• PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity 

  van Setten, Jessica; Brody, Jennifer A.; Jamshidi, Yalda; Swenson, Brenton R.; Butler, Anne M.; Campbell, Harry; Del Greco, Fabiola M.; Evans, Daniel S.; Gibson, Quince; Gudbjartsson, Daniel F.; Kerr, Kathleen F.; Krijthe, Bouwe P.; Lyytikainen, Leo-Pekka; Mueller, Christian; Mueller-Nurasyid, Martina; Nolte, Ilja M.; Padmanabhan, Sandosh; Ritchie, Marylyn D.; Robino, Antonietta; Smith, Albert V.; Steri, Maristella; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; Ulivi, Sheila; Verweij, Niek; Yin, Xiaoyan; Arnar, David O.; Asselbergs, Folkert W.; Bader, Joel S.; Barnard, John; Bis, Josh; Blankenberg, Stefan; Boerwinkle, Eric; Bradford, Yuki; Buckley, Brendan M.; Chung, Mina K.; Crawford, Dana; den Hoed, Marcel; Denny, Josh C.; Dominiczak, Anna F.; Ehret, Georg B.; Eijgelsheim, Mark; Ellinor, Patrick T.; Felix, Stephan B.; Franco, Oscar H.; Franke, Lude; Harris, Tamara B.; Holm, Hilma; Ilaria, Gandin; Iorio, Annamaria; Kahonen, Mika; Kolcic, Ivana; Kors, Jan A.; Lakatta, Edward G.; Launer, Lenore J.; Lin, Honghuang; Lin, Henry J.; Loos, Ruth J. F.; Lubitz, Steven A.; Macfarlane, Peter W.; Magnani, Jared W.; Leach, Irene Mateo; Meitinger, Thomas; Mitchell, Braxton D.; Munzel, Thomas; Papanicolaou, George J.; Peters, Annette; Pfeufer, Arne; Pramstaller, Peter P.; Raitakari, Olli T.; Rotter, Jerome I.; Rudan, Igor; Samani, Nilesh J.; Schlessinger, David; Aldana, Claudia T. Silva; Sinner, Moritz F.; Smith, Jonathan D.; Snieder, Harold; Soliman, Elsayed Z.; Spector, Timothy D.; Stott, David J.; Strauch, Konstantin; Tarasov, Kirill V.; Thorsteinsdottir, Unnur; Uitterlinden, Andre G.; Van Wagoner, David R.; Voelker, Uwe; Voelzke, Henry; Waldenberger, Melanie; Westra, Harm Jan; Wild, Philipp S.; Zeller, Tanja; Alonso, Alvaro; Avery, Christy L.; Bandinelli, Stefania; Benjamin, Emelia J.; Cucca, Francesco; Doerr, Marcus; Ferrucci, Luigi; Gasparini, Paolo; Gudnason, Vilmundur; Hayward, Caroline; Heckbert, Susan R.; Hicks, Andrew A.; Jukema, J. Wouter; Kaeaeb, Stefan; Lehtimaki, Terho; Liu, Yongmei; Munroe, Patricia B.; Parsa, Afshin; Polasek, Ozren; Psaty, Bruce M.; Roden, Dan M.; Schnabel, Renate B.; Sinagra, Gianfranco; Stefansson, Kari; Stricker, Bruno H.; van der Harst, Pim; van Duijn, Cornelia M.; Wilson, James F.; Gharib, Sina A.; de Bakker, Paul I. W.; Isaacs, Aaron; Arking, Dan E.; Sotoodehnia, Nona (Springer Nature, 2018)

  Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genomewide association study of over 92,000 ...
• Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology 

  Seyerle, A. A.; Sitlani, C. M.; Noordam, R.; Gogarten, S. M.; Li, J.; Li, X.; Evans, D. S.; Sun, F.; Laaksonen, M. A.; Isaacs, A.; Kristiansson, K.; Highland, H. M.; Stewart, J. D.; Harris, T. B.; Trompet, S.; Bis, J. C.; Peloso, G. M.; Brody, J. A.; Broer, L.; Busch, E. L.; Duan, Q.; Stilp, A. M.; O'Donnell, C. J.; Macfarlane, P. W.; Floyd, J. S.; Kors, J. A.; Lin, H. J.; Li-Gao, R.; Sofer, T.; Mendez-Giraldez, R.; Cummings, S. R.; Heckbert, S. R.; Hofman, A.; Ford, I; Li, Y.; Launer, L. J.; Porthan, K.; Newton-Cheh, C.; Napier, M. D.; Kerr, K. F.; Reiner, A. P.; Rice, K. M.; Roach, J.; Buckley, Brendan M.; Soliman, E. Z.; de Mutsert, R.; Sotoodehnia, Nona; Uitterlinden, A. G.; North, K. E.; Lee, C. R.; Gudnason, V; Sturmer, T.; Rosendaal, F. R.; Taylor, K. D.; Wiggins, K. L.; Wilson, J. G.; Chen, Y-D, I; Kaplan, R. C.; Wilhelmsen, K.; Cupples, L. A.; Salomaa, V; van Duijn, C.; Jukema, J. W.; Liu, Y.; Mook-Kanamori, D. O.; Lange, L. A.; Vasan, R. S.; Smith, A., V; Stricker, B. H.; Laurie, C. C.; Rotter, J., I; Whitsel, E. A.; Psaty, B. M.; Avery, C. L. (Nature Publishing Group, 2018)

  Thiazide diuretics, commonly used antihypertensives, may cause QT interval (QT) prolongation, a risk factor for highly fatal and difficult to predict ventricular arrhythmias. We examined whether common single-nucleotide ...

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