• The virtually mature BNP (BNP1-32) is a precursor for the more effective BNP1-30 

  Schwiebs, Anja; Wang, Yong; Moore, Andrew M.; Zhu, Xudong; Pankow, Kristin; Siems, Wolf-Eberhard; Walther, Thomas (John Wiley & Sons, Inc., 2019-11-06)

  Background and Purpose: The B‐type natriuretic peptide (BNP1‐32) exerts vasorelaxing and cardioprotective activity. BNP is used as a biomarker for the diagnosis of cardiopathological conditions and recombinant BNP1‐32 as ...
• Placental ageing in adverse pregnancy outcomes: Telomere shortening, cell senescence, and mitochondrial dysfunction 

  Manna, Samprikta; McCarthy, Cathal; McCarthy, Fergus P. (Hindawi, 2019-05-22)

  Preeclampsia is a multisystemic pregnancy disorder and a major cause of maternal and neonatal morbidity and mortality worldwide. The exact pathophysiology of preeclampsia remains unclear; however, it is speculated that the ...
• Age-dependent differences in pulmonary host responses in ARDS: A prospective observational cohort study 

  Schouten, Laura R.; van Kaam, Anton H.; Kohse, Franziska; Veltkamp, Floor; Bos, Lieuwe D.; de Beer, Friso M.; van Hooijdonk, Roosmarijn T.; Horn, Janneke; Straat, Marleen; Witteveen, Esther; Glas, Gerie J.; Wieske, Luuk; van Vught, Lonneke A.; Wiewel, Maryse A.; Ingelse, Sarah A.; Cortjens, Bart; van Woensel, Job B.; Bos, Albert P.; Walther, Thomas; Schultz, Marcus J.; Wösten-van Asperen, Roelie M. (Springer Open, 2019-05-14)

  Background: Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory ...
• Immunomodulatory therapeutic strategies in stroke 

  Malone, Kyle; Amu, Sylvie; Moore, Anne C.; Waeber, Christian (Frontiers Media, 2019-06-20)

  The role of immunity in all stages of stroke is increasingly being recognised, from the pathogenesis of risk factors to tissue repair, leading to the investigation of a range of immunomodulatory therapies. In the acute ...
• Activation of a TLR9 mediated innate immune response in preeclampsia 

  Williamson, Rachel D.; McCarthy, Fergus P.; Kenny, Louise C.; McCarthy, Cathal M. (Nature Publishing Group, 2019-04-11)

  Preeclampsia is a multisystemic disorder leading to the development of a placental ischemic microenvironment with a resultant increase in oxidative stress. There is evidence that mitochondrial dysfunction and the innate ...

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