Pharmacology and Therapeutics

Pharmacology and Therapeutics

Recently added

  • Sartawi, Ziad; Schipani, Ernestina; Ryan, Katie B.; Waeber, Christian (Elsevier Ltd, 2017-08-30)
    The lipid mediator sphingosine 1-phosphate (S1P) affects cellular functions in most systems. Interest in its therapeutic potential has increased following the discovery of its G protein-coupled receptors and the recent ...
  • Song, Dan-Dan; Zhang, Tong-Tong; Chen, Jia-Li; Xia, Yun-Fei; Qin, Zheng-Hong; Waeber, Christian; Sheng, Rui (Nature Publishing Group, 2017)
    Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in ...
  • McCrudden, Cian M.; McBride, John W.; McCaffrey, Joanne; Ali, Ahlam A.; Dunne, Nicholas J.; Kett, Vicky L.; Coulter, Jonathan A.; Robson, Tracy; McCarthy, Helen O. (Cell Press, 2017)
    This study aimed to determine the therapeutic benefit of a nanoparticular formulation for the delivery of inducible nitric oxide synthase (iNOS) gene therapy in a model of breast cancer metastasis. Nanoparticles comprising ...
  • Smith, J. Gustav; Felix, Janine F.; Morrison, Alanna C.; Kalogeropoulos, Andreas; Trompet, Stella; Wilk, Jemma B.; Gidlöf, Olof; Wang, Xinchen; Morley, Michael; Mendelson, Michael; Joehanes, Roby; Ligthart, Symen; Shan, Xiaoyin; Bis, Joshua C.; Wang, Ying A.; Sjögren, Marketa; Ngwa, Julius; Brandimarto, Jeffrey; Stott, David J.; Aguilar, David; Rice, Kenneth M.; Sesso, Howard D.; Demissie, Serkalem; Buckley, Brendan M.; Taylor, Kent D.; Ford, Ian; Yao, Chen; Liu, Chunyu; CHARGE-SCD consortium; EchoGen, consortium; QT-IGC consortium; CHARGE-QRS consortium; Sotoodehnia, Nona; van der Harst, Pim; Stricker, Bruno H. Ch; Kritchevsky, Stephen B.; Liu, Yongmei; Gaziano, J. Michael; Hofman, Albert; Moravec, Christine S.; Uitterlinden, André G.; Kellis, Manolis; van Meurs, Joyce B.; Margulies, Kenneth B.; Dehghan, Abbas; Levy, Daniel; Olde, Björn; Psaty, Bruce M.; Cupples, L. Adrienne; Jukema, J. Wouter; Djousse, Luc; Franco, Oscar H.; Boerwinkle, Eric; Boyer, Laurie A.; Newton-Cheh, Christopher; Butler, Javed; Vasan, Ramachandran S.; Cappola, Thomas P.; Smith, Nicholas L. (PLoS, 2016-05-05)
    Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular ...
  • Buckley, Maria M.; O'Brien, Rebecca; Devlin, Michelle; Creed, Aisling A.; Rae, Mark G.; Hyland, Niall P.; Quigley, Eamonn M. M.; McKernan, Declan P.; O'Malley, Dervla (Wiley, 2016-09-27)
    Leptin ameliorates the prosecretory and prokinetic effects of the pro-inflammatory cytokine interleukin-6 on rat colon. Leptin also suppresses the neurostimulatory effects of irritable bowel syndrome plasma, which has ...

View more

This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement