• Decarboxylation of Ang-(1–7) to Ala1-Ang-(1–7) leads to significant changes in pharmacodynamics 

  Tetzner, Anja; Naughton, Maura; Gebolys, Kinga; Eichhorst, Jenny; Sala, Esther; Villacañas, Óscar; Walther, Thomas (Elsevier B.V., 2018-05-21)

  The heptapeptide angiotensin (Ang)–(1–7) is part of the beneficial arm of the renin-angiotensin system. Ang-(1–7) has cardiovascular protective effects, stimulates regeneration, and opposes the often detrimental effects ...
• Drug-gut microbiota interactions: implications for neuropharmacology 

  Walsh, Jacinta; Griffin, Brendan T.; Clarke, Gerard; Hyland, Niall P. (John Wiley & Sons, Inc. on behalf of the British Pharmacological Society, 2018-05-21)

  The fate and activity of drugs are frequently dictated not only by the host per se but also by the microorganisms present in the gastrointestinal tract. The gut microbiome is known to, both directly and indirectly, affect ...
• Synthesis of symmetrically and unsymmetrically substituted S,S-dialkyl phosphonodithioates 

  Jones, David J.; O'Leary, Eileen M.; O'Sullivan, Timothy P. (Elsevier, 2017-09-22)

  Herein, we report the synthesis of a range of S,S-dialkyl phosphonodithioates. Symmetrically substituted analogues were readily prepared from the corresponding phosphonic dichlorides in good to moderate yields, while ...
• DNA vaccination for cervical cancer: Strategic optimisation of RALA mediated gene delivery from a biodegradable microneedle system 

  Cole, Grace; Ali, Ahlam A.; McCrudden, Cian M.; McBride, John W.; McCaffrey, Joanne; Robson, Tracey; Kett, Vicky L.; Dunne, Nicholas J.; Donnelly, Ryan F.; McCarthy, Helen O. (Elsevier, 2018-03-03)

  Dissolvable microneedles can be employed to deliver DNA to antigen presenting cells within the skin. However, this technology faces two main challenges: the poor transfection efficacy of pDNA following release from the ...
• The PHARMS (Patient Held Active Record of Medication Status) feasibility study: a research proposal 

  Walsh, Elaine; Sahm, Laura J.; Kearney, Patricia M.; Smithson, W. Henry; Kerins, David M.; Ngwa, Chrys; Fitzgerald, Ciara; McCarthy, Stephen; Connolly, Eimear; Dalton, Kieran; Byrne, Derina; Carey, Megan; Bradley, Colin (BioMed Central, 2018)

  Objective: Medication errors are a major source of preventable morbidity, mortality and cost and many occur at the times of hospital admission and discharge. Novel interventions (such as new methods of recording medication ...

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