• Cardioprotective effect of fingolimod against calcium paradox-induced myocardial injury in the isolated rat heart 

  Alatrag, Fatma; Amoni, Matthew; Kelly-Laubscher, Roisin; Gwanyanya, Asfree (Canadian Science Publishing, 2021-09-24)

  Fingolimod (FTY720) inhibits Ca2+-permeable, Mg2+-sensitive channels called transient receptor potential melastatin 7 (TRPM7), but its effects on Ca2+ paradox (CP)-induced myocardial damage have not been evaluated. We ...
• Cardioprotective and anti-arrhythmic effects of magnesium pretreatment against ischaemia/reperfusion injury in isoprenaline-induced hypertrophic rat heart 

  Amoni, Matthew; Kelly-Laubscher, Roisin; Petersen, Morea; Gwanyanya, Asfree (Springer, 2015-12-22)

  The effects of magnesium (Mg2+) on ischaemic complications of pathological cardiac hypertrophy are unclear. In this study, we investigated effects of Mg2+ pretreatment on ischaemia/reperfusion (I/R) injury in isoprenaline ...
• Beneficial effects of magnesium treatment on heart rate variability and cardiac ventricular function in diabetic rats 

  Amoni, Matthew; Kelly-Laubscher, Roisin; Blackhurst, Dee; Gwanyanya, Asfree (Sage, 2016-06-08)

  Background: Diabetes mellitus induces life-threatening cardiovascular complications such as cardiac autonomic neuropathy and ventricular dysfunction and is associated with hypomagnesemia. In this study, we investigated the ...
• Ethanolamine is a novel STAT-3 dependent cardioprotective agent 

  Kelly-Laubscher, Roisin; Lamont, Kim T.; Somers, Sarin; Hacking, Damian; Lacerda, Lydia; Thomas, Paul; Opie, Lionel H.; Lecour, Sandrine (Springer, 2010-10-12)

  Ethanolamine is a biogenic amine found naturally in the body as part of membrane lipids and as a metabolite of the cardioprotective substances, sphingosine-1-phosphate (S1P) and anandamide. In the brain, ethanolamine, ...
• Sphingosine 1-phosphate, a potential target in neovascular retinal disease 

  Alshaikh, Rasha A.; Ryan, Katie B.; Waeber, Christian (BMJ Publishing Group, 2021-05-07)

  Neovascular ocular diseases (such as age-related macular degeneration, diabetic retinopathy and retinal vein occlusion) are characterised by common pathological processes that contribute to disease progression. These include ...

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