• Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology 

  Seyerle, A. A.; Sitlani, C. M.; Noordam, R.; Gogarten, S. M.; Li, J.; Li, X.; Evans, D. S.; Sun, F.; Laaksonen, M. A.; Isaacs, A.; Kristiansson, K.; Highland, H. M.; Stewart, J. D.; Harris, T. B.; Trompet, S.; Bis, J. C.; Peloso, G. M.; Brody, J. A.; Broer, L.; Busch, E. L.; Duan, Q.; Stilp, A. M.; O'Donnell, C. J.; Macfarlane, P. W.; Floyd, J. S.; Kors, J. A.; Lin, H. J.; Li-Gao, R.; Sofer, T.; Mendez-Giraldez, R.; Cummings, S. R.; Heckbert, S. R.; Hofman, A.; Ford, I; Li, Y.; Launer, L. J.; Porthan, K.; Newton-Cheh, C.; Napier, M. D.; Kerr, K. F.; Reiner, A. P.; Rice, K. M.; Roach, J.; Buckley, Brendan M.; Soliman, E. Z.; de Mutsert, R.; Sotoodehnia, N.; Uitterlinden, A. G.; North, K. E.; Lee, C. R.; Gudnason, V; Sturmer, T.; Rosendaal, F. R.; Taylor, K. D.; Wiggins, K. L.; Wilson, J. G.; Chen, Y-D, I; Kaplan, R. C.; Wilhelmsen, K.; Cupples, L. A.; Salomaa, V; van Duijn, C.; Jukema, J. W.; Liu, Y.; Mook-Kanamori, D. O.; Lange, L. A.; Vasan, R. S.; Smith, A., V; Stricker, B. H.; Laurie, C. C.; Rotter, J., I; Whitsel, E. A.; Psaty, B. M.; Avery, C. L. (Nature Publishing Group, 2018)

  Thiazide diuretics, commonly used antihypertensives, may cause QT interval (QT) prolongation, a risk factor for highly fatal and difficult to predict ventricular arrhythmias. We examined whether common single-nucleotide ...
• The immune system and stroke: from current targets to future therapy 

  Malone, Kyle; Amu, Sylvie; Moore, Anne C.; Waeber, Christian (John Wiley & Sons, Inc., 2018-07-19)

  Stroke is a major cause of morbidity and mortality worldwide. Despite the intensive search for new therapies, hundreds of agents targeting various pathophysiological mechanisms have failed clinical trials, and the thrombolytic ...
• Angiotensin-(1-7) counteracts the transforming effects triggered by angiotensin II in breast cancer cells 

  Cambados, Nadia; Walther, Thomas; Nahmod, Karen; Tocci, Johanna M.; Rubinstein, Natalia; Boehme, Ilka; Simian, Marina; Sampayo, Rocio; Del Valle Suberbordes, Melisa; Kordon, Edith C.; Schere-Levy, Carolina (Impact Journals, 2017)

  Angiotensin (Ang) II, the main effector peptide of the renin-angiotensin system, has been implicated in multiple aspects of cancer progression such as proliferation, migration, invasion, angiogenesis and metastasis. ...
• Decarboxylation of Ang-(1–7) to Ala1-Ang-(1–7) leads to significant changes in pharmacodynamics 

  Tetzner, Anja; Naughton, Maura; Gebolys, Kinga; Eichhorst, Jenny; Sala, Esther; Villacañas, Óscar; Walther, Thomas (Elsevier B.V., 2018-05-21)

  The heptapeptide angiotensin (Ang)–(1–7) is part of the beneficial arm of the renin-angiotensin system. Ang-(1–7) has cardiovascular protective effects, stimulates regeneration, and opposes the often detrimental effects ...
• Drug-gut microbiota interactions: implications for neuropharmacology 

  Walsh, Jacinta; Griffin, Brendan T.; Clarke, Gerard; Hyland, Niall P. (John Wiley & Sons, Inc. on behalf of the British Pharmacological Society, 2018-05-21)

  The fate and activity of drugs are frequently dictated not only by the host per se but also by the microorganisms present in the gastrointestinal tract. The gut microbiome is known to, both directly and indirectly, affect ...

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