Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiative

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dc.contributor.author Hofman, Cynthia S.
dc.contributor.author Lutomski, Jennifer E.
dc.contributor.author Boter, Han
dc.contributor.author Buurman, Bianca M.
dc.contributor.author de Craen, Anton J. M.
dc.contributor.author Donders, Rogier
dc.contributor.author Olde Rikkert, Marcel G. M.
dc.contributor.author Makai, Peter
dc.contributor.author Melis, René J. F.
dc.contributor.author TOPICS-MDS research consortium
dc.date.accessioned 2017-04-10T10:34:29Z
dc.date.available 2017-04-10T10:34:29Z
dc.date.issued 2017-03-15
dc.identifier.citation Hofman, C. S., Lutomski, J. E., Boter, H., Buurman, B. M., de Craen, A. J. M., Donders R., et al. (2017) ‘Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiative’, PLoS ONE 12(3): e0173081 (12pp). doi:10.1371/journal.pone.0173081 en
dc.identifier.volume 12 en
dc.identifier.issued 3 en
dc.identifier.startpage 1 en
dc.identifier.endpage 12 en
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10468/3865
dc.identifier.doi 10.1371/journal.pone.0173081
dc.description.abstract Background: Preference-weighted multi-faceted endpoints have the potential to facilitate comparative effectiveness research that incorporates patient preferences. The Older Persons and Informal Caregivers Survey—Composite endpoint (TOPICS-CEP) is potentially a valuable outcome measure for evaluating interventions in geriatric care as it combines multiple outcomes relevant to older persons in a single metric. The objective of this study was to validate TOPICS-CEP across different study settings (general population, primary care and hospital). Methods: Data were extracted from TOPICS Minimum Dataset (MDS), a pooled public-access national database with information on older persons throughout the Netherlands. Data of 17,603 older persons were used. Meta-correlations were performed between TOPICS-CEP indexed scores, EuroQol5-D utility scores and Cantril’s ladder life satisfaction scores. Mixed linear regression analyses were performed to compare TOPICS-CEP indexed scores between known groups, e.g. persons with versus without depression. Results: In the complete sample and when stratified by study setting TOPICS-CEP and Cantril’s ladder were moderately correlated, whereas TOPICS-CEP and EQ-5D were highly correlated. Higher mean TOPICS-CEP scores were found in persons who were: married, lived independently and had an education at university level. Moreover, higher mean TOPICS-CEP scores were found in persons without dementia, depression, and dizziness with falls, respectively. Similar results were found when stratified by subgroup. Conclusion: This study supports that TOPICS-CEP is a robust measure which can potentially be used in broad settings to identify the effect of intervention or of prevention in elderly care. en
dc.description.sponsorship ZonMw, The Netherlands (Dutch National Care for the Elderly Programme, Grant number: 60-61900-98-302) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Public Library of Science en
dc.relation.uri https://doi.org/10.6084/m9.figshare.4697542.v1
dc.rights © 2017, Hofman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Quality of life en
dc.subject Health status en
dc.subject Patient groups en
dc.subject Care en
dc.subject Adults en
dc.title Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiative en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Jennifer Lutomski, Obstetrics & Gynaecology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.lutomski@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-03-31T10:50:30Z
dc.description.version Published Version en
dc.internal.rssid 389399767
dc.internal.wokid WOS:000396311700025
dc.contributor.funder ZonMw en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Plos One en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress j.lutomski@ucc.ie en
dc.identifier.articleid e0173081


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© 2017, Hofman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as © 2017, Hofman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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