Bacteriocin Gene-Trait matching across the complete Lactobacillus Pan-genome

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dc.contributor.author Collins, Fergus W. J.
dc.contributor.author O'Connor, Paula M.
dc.contributor.author O'Sullivan, Orla
dc.contributor.author Gómez-Sala, Beatriz
dc.contributor.author Rea, Mary C.
dc.contributor.author Hill, Colin
dc.contributor.author Ross, R. Paul
dc.date.accessioned 2017-06-23T08:46:30Z
dc.date.available 2017-06-23T08:46:30Z
dc.date.issued 2017-06
dc.identifier.citation Collins, F. W. J., O’Connor, P. M., O’Sullivan, O., Gómez-Sala, B., Rea, M. C., Hill, C. and Ross, R. P. (2017) 'Bacteriocin Gene-Trait matching across the complete Lactobacillus Pan-genome', Scientific Reports, 7(1), 3481. doi:10.1038/s41598-017-03339-y en
dc.identifier.volume 7 en
dc.identifier.issued 1 en
dc.identifier.startpage 3481-1 en
dc.identifier.endpage 3481-14 en
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10468/4181
dc.identifier.doi 10.1038/s41598-017-03339-y
dc.description.abstract Lactobacilli constitute a large genus of Gram-positive lactic acid bacteria which have widespread roles ranging from gut commensals to starters in fermented foods. A combination of in silico and laboratory-based screening allowed us to determine the overall bacteriocin producing potential of representative strains of each species of the genus. The genomes of 175 lactobacilli and 38 associated species were screened for the presence of antimicrobial producing genes and combined with screening for antimicrobial activity against a range of indicators. There also appears to be a link between the strains’ environment and bacteriocin production, with those from the animal and human microbiota encoding over twice as many bacteriocins as those from other sources. Five novel bacteriocins were identified belonging to differing bacteriocin classes, including two-peptide bacteriocins (muricidin and acidocin X) and circular bacteriocins (paracyclicin). In addition, there was a clear clustering of helveticin type bacteriolysins in the Lactobacillus acidophilus group of species. This combined in silico and in vitro approach to screening has demonstrated the true diversity and complexity of bacteriocins across the genus. It also highlights their biological importance in terms of communication and competition between closely related strains in diverse complex microbial environments. en
dc.description.sponsorship Science Foundation Ireland (SFI Grant Number SFI/12/RC/227; Starting Investigator Research Grant award (13/SIRG/2160)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Nature Publishing Group en
dc.rights © The Authors 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Antimicrobials en
dc.subject Bacteria en
dc.subject Fermented foods en
dc.subject Lactic acid bacteria en
dc.title Bacteriocin Gene-Trait matching across the complete Lactobacillus Pan-genome en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Paul Ross, College Of Sefs Office, University College Cork, Cork, Ireland. +353-21-490-3000 Email: p.ross@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-06-23T08:40:14Z
dc.description.version Published Version en
dc.internal.rssid 400214301
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Scientific Reports en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress p.ross@ucc.ie en


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© The Authors 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Except where otherwise noted, this item's license is described as © The Authors 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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