• Impact of host and environmental factors on β-glucuronidase enzymatic activity: implications for gastrointestinal serotonin 

  Walsh, Jacinta; Olavarria-Ramirez, Loreto; Lach, Gilliard; Boehme, Marcus; Dinan, Timothy G.; Cryan, John F.; Griffin, Brendan T.; Hyland, Niall P.; Clarke, Gerard (American Physiological Society, 2020-03-09)

  The gastrointestinal tract houses a reservoir of bacterial-derived enzymes which can directly catalyze the metabolism of drugs, dietary elements, and endogenous molecules. Both host and environmental factors may influence ...
• Association between preeclampsia and attention deficit hyperactivity disorder: a population-based and sibling-matched cohort study 

  Maher, Gillian M.; Dalman, Christina; O'Keeffe, Gerard W.; Kearney, Patricia M.; McCarthy, Fergus P.; Kenny, Louise C.; Khashan, Ali S. (Wiley, 2020-02-13)

  Objective: Examine the association between preeclampsia and attention deficit hyperactivity disorder (ADHD), using a large Swedish‐based registry cohort. Methods: This study comprised 2,047,619 children, with 114,934 (5.6%) ...
• Application of a physiologically-based pharmacokinetic model for the prediction of bumetanide plasma and brain concentrations in the neonate 

  Donovan, Maria D.; Abduljalil, Khaled; Cryan, John F.; Boylan, Geraldine B.; Griffin, Brendan T. (Wiley, 2018-01-10)

  Bumetanide is a loop diuretic that is proposed to possess a beneficial effect on disorders of the central nervous system, including neonatal seizures. Therefore, prediction of unbound bumetanide concentrations in the brain ...
• Programming bugs: microbiota and the developmental origins of brain health and disease 

  Codagnone, Martin G.; Spichak, Simon; O'Mahony, Siobhain M.; O'Leary, Olivia F.; Clarke, Gerard; Stanton, Catherine; Dinan, Timothy G.; Cryan, John F. (Elsevier, 2018-06-27)

  It has been nearly 30 years since Dr. David Barker first highlighted the importance of prenatal factors in contributing to the developmental origins of adult disease. This concept was later broadened to include postnatal ...
• Epigenetic silencing by early life hypoxic stress programmes respiratory motor control 

  O'Connor, Karen M.; Dias, Maria L.; McDonald, Fiona B.; O'Halloran, Ken D. (John Wiley & Sons, Inc., 2019-11-04)

  Preterm birth is a risk factor for the development of cardiorespiratory complications. Infants that are born prematurely face myriad challenges due to physiological immaturity. Respiratory control impairments in early life ...

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