Gold nanoparticles enlighten the future of cancer theranostics

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Date
2017-08
Authors
Guo, Jianfeng
Rahme, Kamil
He, Yan
Li, Lin-Lin
Holmes, Justin D.
O'Driscoll, Caitríona M.
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Dove Medical Press
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Abstract
Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bioimaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed “theranostics,” multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed.
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Keywords
Multifunctional gold nanoparticles , Cancer bioimaging , Cancer photothermal and photodynamic therapy , Near-infrared light , Scattering submicroscopic particles , Enhanced photothermal therapy , Highly fluorescent analogs , Surface-plasmon resonance , Nucleic-acid delivery , In-vivo , Photodynamic therapy , Optical-properties , Sirna delivery
Citation
Guo, J., Rahme, K., He, Y., Li, L., Ho,lmes, J. D. and O'Driscoll, C. M. (2017) 'Gold nanoparticles enlighten the future of cancer theranostics'. International Journal of Nanomedicine, 12, pp. 6131-6152. doi: 10.2147/IJN.S140772