Identification of secondary metabolite gene clusters in the Pseudovibrio genus reveals encouraging biosynthetic potential toward the production of novel bioactive compounds

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dc.contributor.author Naughton, Lynn M.
dc.contributor.author Romano, Stefano
dc.contributor.author O'Gara, Fergal
dc.contributor.author Dobson, Alan D. W.
dc.date.accessioned 2017-09-26T11:39:22Z
dc.date.available 2017-09-26T11:39:22Z
dc.date.issued 2017
dc.identifier.citation Naughton, L. M., Romano, S., O’Gara, F. and Dobson, A. D. W. (2017) 'Identification of secondary metabolite gene clusters in the Pseudovibrio genus reveals encouraging biosynthetic potential toward the production of novel bioactive compounds', Frontiers in Microbiology, 8, 1494 (15pp). doi: 10.3389/fmicb.2017.01494 en
dc.identifier.volume 8
dc.identifier.issn 1664-302X
dc.identifier.uri http://hdl.handle.net/10468/4801
dc.identifier.doi 10.3389/fmicb.2017.01494
dc.description.abstract Increased incidences of antimicrobial resistance and the emergence of pan-resistant 'superbugs' have provoked an extreme sense of urgency amongst researchers focusing on the discovery of potentially novel antimicrobial compounds. A strategic shift in focus from the terrestrial to the marine environment has resulted in the discovery of a wide variety of structurally and functionally diverse bioactive compounds from numerous marine sources, including sponges. Bacteria found in close association with sponges and other marine invertebrates have recently gained much attention as potential sources of many of these novel bioactive compounds. Members of the genus Pseudovibrio are one such group of organisms. In this study, we interrogate the genomes of 21 Pseudovibrio strains isolated from a variety of marine sources, for the presence, diversity and distribution of biosynthetic gene clusters (BGCs). We expand on results obtained from antiSMASH analysis to demonstrate the similarity between the Pseudovibriorelated BGCs and those characterized in other bacteria and corroborate our findings with phylogenetic analysis. We assess how domain organization of the most abundant type of BGCs present among the isolates (Non-ribosomal peptide synthetases and Polyketide synthases) may influence the diversity of compounds produced by these organisms and highlight for the first time the potential for novel compound production from this genus of bacteria, using a genome guided approach. en
dc.description.sponsorship Department of Agriculture, Food and the Marine (FIRM 1/F009/MabS, FIRM 13/F/516); Marine Institute (National Development Plan; Sea Change Strategy and the Strategy for Science Technology and Innovation; Beaufort award (C2CRA 2007/082) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media S.A. en
dc.relation.uri http://journal.frontiersin.org/article/10.3389/fmicb.2017.01494/full
dc.rights © 2017, Naughton, Romano, O’Gara and Dobson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Symbiont en
dc.subject PKS en
dc.subject NRPS en
dc.subject Antibiotic resistance en
dc.subject Bioactive compounds en
dc.subject Nonribosomal peptide synthetases en
dc.subject Marine natural products en
dc.subject Neighbor joining method en
dc.subject Polyketide synthases en
dc.subject Colibactin biosynthesis en
dc.subject Sp nov en
dc.subject Sponges en
dc.subject Discovery en
dc.subject Bacteria en
dc.subject Actinomycete en
dc.title Identification of secondary metabolite gene clusters in the Pseudovibrio genus reveals encouraging biosynthetic potential toward the production of novel bioactive compounds en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Alan Dobson, Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.dobson@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.internal.wokid WOS:000407899300001
dc.contributor.funder European Social Fund
dc.contributor.funder Marine Institute
dc.contributor.funder Department of Agriculture, Food and the Marine
dc.contributor.funder Science Foundation Ireland
dc.contributor.funder Seventh Framework Programme
dc.contributor.funder European Commission
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Microbiology en
dc.internal.IRISemailaddress a.dobson@ucc.ie en
dc.identifier.articleid 1494
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/607786/EU/BluePharmTrain/BLUEPHARMTRAIN
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/264266/EU/Towards a Latin America & Caribbean Knowledge Based Bio-Economy (KBBE) in partnership with Europe/ALCUE-KBBE


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© 2017, Naughton, Romano, O’Gara and Dobson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms Except where otherwise noted, this item's license is described as © 2017, Naughton, Romano, O’Gara and Dobson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
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