Bacterial toxins: Offensive, defensive, or something else altogether?

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Rudkin, Justine K.
McLoughlin, Rachel M.
Preston, Andrew
Massey, Ruth C.
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Public Library of Science
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The secretion of proteins that damage host tissue is well established as integral to the infectious processes of many bacterial pathogens. However, recent advances in our understanding of the activity of toxins suggest that the attributes we have assigned to them from early in vitro experimentation have misled us into thinking of them as merely destructive tools. Here, we will discuss the multifarious ways in which toxins contribute to the lifestyle of bacteria and, by considering their activity from an evolutionary perspective, demonstrate how this extends far beyond their ability to destroy host tissue
Toxins , Bacterial pathogens , Bacterial biofilms , Staphylococcus aureus , Host cells , Biofilms , Bordetella pertussis , Nose
Rudkin, J. K., McLoughlin, R. M., Preston, A. and Massey, R. C. (2017) 'Bacterial toxins: Offensive, defensive, or something else altogether?', PLOS Pathogens, 13(9), e1006452 (12pp). doi: 10.1371/journal.ppat.1006452