Adiposity associated plasma linoleic acid is related to demographic, metabolic health and haplotypes of FADS1/2 genes in Irish adults

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dc.contributor.author Li, Kaifeng
dc.contributor.author Brennan, Lorraine
dc.contributor.author Bloomfield, Jack F.
dc.contributor.author Duff, Dan J.
dc.contributor.author McNulty, Breige A.
dc.contributor.author Flynn, Albert
dc.contributor.author Walton, Janette
dc.contributor.author Gibney, Michael J.
dc.contributor.author Nugent, Anne P.
dc.date.accessioned 2018-02-13T10:08:12Z
dc.date.available 2018-02-13T10:08:12Z
dc.date.issued 2018-02-01
dc.identifier.citation Li, K., Brennan, L., Bloomfield, J. F., Duff, D. J., McNulty, B. A., Flynn, A., Walton, J., Gibney, M. J. and Nugent, A. P. (2018) 'Adiposity associated plasma linoleic acid is related to demographic, metabolic health and haplotypes of FADS1/2 genes in Irish adults', Molecular Nutrition and Food Research. doi:10.1002/mnfr.201700785 en
dc.identifier.issn 1613-4133
dc.identifier.uri http://hdl.handle.net/10468/5446
dc.identifier.doi 10.1002/mnfr.201700785
dc.description.abstract Scope: This study examined to what extent plasma linoleic acid (LA) is modified by adiposity, and explored any association between plasma LA, demographics, dietary intakes, markers of metabolic health and haplotypes of the fatty acid desaturase (FADS) 1/2 genes. Methods and results: 820 participants with fasting blood samples from Irish National Adult Nutrition Survey were studied. Plasma fatty acids were determined using GC-MS. 15 SNPs of FADS 1/2 genes were genotyped. Plasma LA decreased while γ-linoleic acid and dihomo-γ-linoleic acid increased in overweight/obese participants (P ≤ 0.002). Participants in the highest quartile of plasma LA showed decreased plasma markers of de novo lipogenesis, insulin resistance and of inflammation (TNF-α, PAI-1) (P ≤ 0.005). Adiposity (waist circumference and body fat) was strongly inversely associated with plasma LA accounting for 11.8% of variance observed, which was followed by FADS1/2 haplotypes (3.9 %), quantity and quality of carbohydrate intakes (3.8 %), dietary PUFA intakes (3.7 %), systolic blood pressure (3.6 %) and age (3.2 %). Conclusion: Plasma LA was inversely associated with adiposity, followed by haplotypes of FADS1/2 genes, carbohydrate intakes and dietary PUFA intakes. The association observed between plasma LA and adiposity may be linked to decreased de novo lipogenesis, insulin resistance and inflammation. en
dc.description.sponsorship Department of Agriculture, Food and the Marine / Health Research Board (Food for Health Research Initiative: Grant Number FHRIUCC2); China Scholarship Council (PhD studentship) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher John Wiley & Sons, Inc. en
dc.rights © 2018, John Wiley & Sons, Inc. All rights reserved. This is the peer reviewed version of the following article: Li, K., Brennan, L., Bloomfield, J. F., Duff, D. J., McNulty, B. A., Flynn, A., Walton, J., Gibney, M. J. and Nugent, A. P. (2018) 'Adiposity associated plasma linoleic acid is related to demographic, metabolic health and haplotypes of FADS1/2 genes in Irish adults', Molecular Nutrition and Food Research, which has been published in final form at https://doi.org/10.1002/mnfr.201700785. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject FADS1 en
dc.subject FADS2 en
dc.subject Genotype en
dc.subject Linoleic acid en
dc.title Adiposity associated plasma linoleic acid is related to demographic, metabolic health and haplotypes of FADS1/2 genes in Irish adults en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Albert Flynn, Food and Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.flynn@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-02-01
dc.date.updated 2018-02-09T10:06:03Z
dc.description.version Accepted Version en
dc.internal.rssid 425097069
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.contributor.funder Health Research Board en
dc.contributor.funder China Scholarship Council en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Molecular Nutrition and Food Research en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress a.flynn@ucc.ie en
dc.internal.IRISemailaddress janette.walton@ucc.ie en
dc.internal.bibliocheck In press. Check vol / issue / page range / publication date. Amend citation / embargo as necessary.


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