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Placental Growth Factor: A review of literature and future applications
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Accepted version
Date
2018-03-10
Authors
Hayes-Ryan, Deirdre
McCarthy, Fergus P.
O'Donoghue, Keelin
Kenny, Louise C.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Published Version
Abstract
Placental growth factor is an angiogenic protein, highly expressed during pregnancy, which correlates well with placental function. In this review, we highlight the origin, structure and function of Placental Growth Factor and its receptors. We discuss how their pro-angiogenic/anti-angiogenic synergism is critical for successful placentation and how their imbalance may be utilised as a diagnostic marker of disease or a potential therapeutic target for adverse pregnancy outcomes.
Description
Keywords
Placental growth factor (PlGF) , PlGF concentrations , Pre-eclampsia , Adverse pregnancy outcomes , Pregnancy
Citation
Hayes Ryan, D., McCarthy, F. P., O'Donoghue, K. and Kenny, L. C. 'Placental Growth Factor: A review of literature and future applications', Pregnancy Hypertension, In Press. doi: 10.1016/j.preghy.2018.03.003