Polydopamine nanoparticles for treatment of acute inflammation-induced injury

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dc.contributor.author Zhao, He
dc.contributor.author Zeng, Zhandong
dc.contributor.author Liu, Lin
dc.contributor.author Chen, Jiawen
dc.contributor.author Zhou, Huiting
dc.contributor.author Huang, Lili
dc.contributor.author Huang, Jie
dc.contributor.author Xu, Hua
dc.contributor.author Xu, Yunyun
dc.contributor.author Chen, Zhengrong
dc.contributor.author Wu, Yi
dc.contributor.author Guo, Wanliang
dc.contributor.author Wang, Jiang Huai
dc.contributor.author Wang, Jian
dc.contributor.author Liu, Zhuang
dc.date.accessioned 2018-03-27T08:59:15Z
dc.date.available 2018-03-27T08:59:15Z
dc.date.issued 2018-03-13
dc.identifier.citation Zhao, H., Zeng, Z., Liu, L., Chen, J., Zhou, H., Huang, L., Huang, J., Xu, H., Xu, Y., Chen, Z., Wu, Y., Guo, W., Wang, J. H., Wang, J. and Liu, Z. (2018) 'Polydopamine nanoparticles for treatment of acute inflammation-induced injury', Nanoscale. doi:10.1039/C8NR00838H en
dc.identifier.issn 2040-3364
dc.identifier.uri http://hdl.handle.net/10468/5695
dc.identifier.doi 10.1039/C8NR00838H
dc.description.abstract Nanotechnology-mediated anti-inflammatory therapy is emerging as a novel strategy for treatment of inflammation-induced injury. However, one of the main hurdles for these anti-inflammatory nano-drugs is their potential toxic side effects in vivo. Herein, we uncovered that polydopamine (PDA) nanoparticles with structure and chemical properties similar to melanin, a natural bio-polymer, displayed significant anti-inflammation therapeutic effect on acute inflammation-induced injury. PDA with enriched phenol groups functioned as a radical scavenger to eliminate reactive oxygen species (ROS) generated during inflammatory responses. As revealed by in vivo photoacoustic imaging with a H2O2-specific nanoprobe, PDA nanoparticles remarkably reduced intracellular ROS levels in murine macrophages challenged with either H2O2 or lipopolysaccharide (LPS). The anti-inflammatory capacity of PDA nanoparticles was further demonstrated in murine models of both acute peritonitis and acute lung injury (ALI), where diminished ROS generation, reduced proinflammatory cytokines, attenuated neutrophil infiltration, and alleviated lung tissue damage were observed in PDA-treated mice after a single dose of PDA treatment. Our work therefore presents the great promise of PDA nanoparticles as a biocompatible nano-drug for anti-inflammation therapy to treat acute inflammation-induced injury. en
dc.description.sponsorship Ministry of Science and Technology of the People´s Republic of China (National Basic Research Programs of China - 973Program (2016YFA0201200)); National Natural Science Foundation of China (81602181, 81501703, 81500733, 81502500, 81420108022, 81272143, 51525203, 31300824, 81701948); Natural Science Foundation of Jiangsu Province (BK20150292, 20150293, 20150294); Suzhou Municipal Science and Technology Project (SYS201565, SYS201759); Key Laboratory of Suzhou (SZS201307); Suzhou Clinical Medicine Center (Szzxj201505); Jiangsu Natural Science Fund for Distinguished Young Scholars (BK20130005); Jiangsu Higher Education Institutions (Priority Academic Program Development) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Royal Society of Chemistry en
dc.rights © 2018, the Authors. Published by the Royal Society of Chemistry. All rights reserved. This document is the accepted version of an article published in final form in Nanoscale. To access the final published work see http://dx.doi.org/10.1039/C8NR00838H en
dc.subject Polydopamine en
dc.subject Acute inflammation injury en
dc.subject Reactive oxygen species en
dc.subject Anti-inflammation therapy en
dc.title Polydopamine nanoparticles for treatment of acute inflammation-induced injury en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Jianghuai Wang, Surgery, University College Cork, Cork, Ireland. +353-21-490-3000 Email: jh.wang@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-03-13
dc.date.updated 2018-03-21T12:03:11Z
dc.description.version Accepted Version en
dc.internal.rssid 430788387
dc.contributor.funder Ministry of Science and Technology of the People's Republic of China en
dc.contributor.funder National Natural Science Foundation of China en
dc.contributor.funder Natural Science Foundation of Jiangsu Province en
dc.contributor.funder Suzhou Municipal Science and Technology Project, China
dc.contributor.funder Key Laboratory of Suzhou, China
dc.contributor.funder Suzhou Clinical Medicine Center, China
dc.contributor.funder Jiangsu Natural Science Fund for Distinguished Young Scholars
dc.contributor.funder Jiangsu Higher Education Institutions, China
dc.contributor.funder Collaborative Innovation Center of Suzhou Nano Science and Technology, China
dc.description.status Peer reviewed en
dc.identifier.journaltitle Nanoscale en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress jh.wang@ucc.ie en
dc.internal.bibliocheck In Press. Check for vol. / issue / page numbers. Amend citation as necessary.

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