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Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide
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Accepted version
Date
2018-03-17
Authors
Henze, Laura J.
Griffin, Brendan T.
Christiansen, Martin
Bundgaard, Christoffer
Langguth, Peter
Holm, René
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Published Version
Abstract
The present study investigated the gastric emptying rate in Göttingen minipigs pre- and post-prandial and evaluated the effect of metoclopramide on the same parameter, using paracetamol as an absorption marker. The pharmacokinetic evaluation of the obtained plasma concentration data for paracetamol demonstrated that the fastest gastric emptying rate was observed in the animals that were allowed access to normal pig food. There was no significant difference in the stomach emptying rate observed between fasted and fed minipigs, when fed either with a FDA standard breakfast or a nutritional energy drink. Pre-dosing minipigs with metoclopramide (0.2 or 0.4 mg/kg) did not demonstrate any effect on gastric emptying in either the fasted or fed state. The data in the present study demonstrated a relatively prolonged gastric emptying rate in mini-pigs both in the fasted and fed state, hence when conducting pharmacokinetic studies using mini-pigs, this should be taken into account in planning the plasma sampling time points. Further, as no difference could be observe in gastric emptying rate as a function of food the data also suggest that the Göttingen minipigs seems less suited to predict for food effect studies than other species.
Description
Keywords
Gastric emptying , Mini-pigs , Metoclopramide , Fasted state , Fed state
Citation
Henze, L. J., Griffin, B. T., Christiansen, M., Bundgaard, C., Langguth, P. and Holm, R. (2018) 'Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide', European Journal of Pharmaceutical Sciences, In Press. doi: 10.1016/j.ejps.2018.03.017