Staying alive! Sensors used for monitoring cell health in bioreactors

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dc.contributor.author O'Mara, Paul
dc.contributor.author Farrell, Amy
dc.contributor.author Bones, Jonathan
dc.contributor.author Twomey, Karen
dc.date.accessioned 2018-05-25T10:32:20Z
dc.date.available 2018-05-25T10:32:20Z
dc.date.issued 2017-07-29
dc.identifier.citation O’Mara, P., Farrell, A., Bones, J. and Twomey, K. (2018) 'Staying alive! Sensors used for monitoring cell health in bioreactors', Talanta, 176, pp. 130-139. doi: 10.1016/j.talanta.2017.07.088 en
dc.identifier.volume 176 en
dc.identifier.startpage 130 en
dc.identifier.endpage 139 en
dc.identifier.issn 0039-9140
dc.identifier.uri http://hdl.handle.net/10468/6193
dc.identifier.doi 10.1016/j.talanta.2017.07.088
dc.description.abstract Current and next generation sensors such as pH, dissolved oxygen (dO) and temperature sensors that will help drive the use of single-use bioreactors in industry are reviewed. The current trend in bioreactor use is shifting from the traditional fixed bioreactors to the use of single-use bioreactors (SUBs). However as the shift in paradigm occurs there is now a greater need for sensor technology to play â catch upâ with the innovation of bioreactor technology. Many of the sensors still in use today rely on technology created in the 1960's such as the Clark-type dissolved oxygen sensor or glass pH electrodes. This is due to the strict requirements of sensors to monitor bioprocesses resulting in the use of traditional well understood methods, making it difficult to incorporate new sensor technology into industry. A number of advances in sensor technology have been achieved in recent years, a few of these advances and future research will also be discussed in this review. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier B.V. en
dc.rights © 2017, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Bioreactor en
dc.subject Electrochemical sensors en
dc.subject Optical sensors en
dc.subject Capsule technology en
dc.subject pH en
dc.subject Dissolved oxygen en
dc.subject Temperature en
dc.subject Microfabrication en
dc.subject Process analytical technology en
dc.title Staying alive! Sensors used for monitoring cell health in bioreactors en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Karen Twomey, Tyndall Microsystems, University College Cork, Cork, Ireland. +353-21-490-3000 Email: karen.twomey@tyndall.ie en
dc.internal.availability Full text not available en
dc.check.info Access to this article is restricted for 24 months after publication by request of the publisher. en
dc.check.date 2019-07-29
dc.date.updated 2018-05-25T09:04:25Z
dc.description.version Accepted Version en
dc.internal.rssid 439007217
dc.description.status Peer reviewed en
dc.identifier.journaltitle Talanta en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress karen.twomey@tyndall.ie en


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© 2017, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2017, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
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