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Staying alive! Sensors used for monitoring cell health in bioreactors
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Accepted Version
Date
2017-07-29
Authors
O'Mara, Paul
Farrell, Amy
Bones, Jonathan
Twomey, Karen
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier B.V.
Published Version
Abstract
Current and next generation sensors such as pH, dissolved oxygen (dO) and temperature sensors that will help drive the use of single-use bioreactors in industry are reviewed. The current trend in bioreactor use is shifting from the traditional fixed bioreactors to the use of single-use bioreactors (SUBs). However as the shift in paradigm occurs there is now a greater need for sensor technology to play â catch upâ with the innovation of bioreactor technology. Many of the sensors still in use today rely on technology created in the 1960's such as the Clark-type dissolved oxygen sensor or glass pH electrodes. This is due to the strict requirements of sensors to monitor bioprocesses resulting in the use of traditional well understood methods, making it difficult to incorporate new sensor technology into industry. A number of advances in sensor technology have been achieved in recent years, a few of these advances and future research will also be discussed in this review.
Description
Keywords
Bioreactor , Electrochemical sensors , Optical sensors , Capsule technology , pH , Dissolved oxygen , Temperature , Microfabrication , Process analytical technology
Citation
O’Mara, P., Farrell, A., Bones, J. and Twomey, K. (2018) 'Staying alive! Sensors used for monitoring cell health in bioreactors', Talanta, 176, pp. 130-139. doi: 10.1016/j.talanta.2017.07.088