Microbial therapeutics for infant gut health

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dc.contributor.advisor O'Toole, Paul W. en
dc.contributor.advisor Stanton, Catherine en
dc.contributor.advisor Ryan, C. Anthony en
dc.contributor.author Watkins, Claire
dc.date.accessioned 2018-06-12T11:08:30Z
dc.date.available 2018-06-12T11:08:30Z
dc.date.issued 2018
dc.date.submitted 2018
dc.identifier.citation Watkins, C. 2018. Microbial therapeutics for infant gut health. PhD Thesis, University College Cork. en
dc.identifier.uri http://hdl.handle.net/10468/6279
dc.description.abstract The infant gut microbiota play an important role in the development of human health. This thesis outlines different areas where the infant gut can contribute as a source of microorganisms with the potential to benefit health. In addition, the use of microbial therapeutics is discussed to highlight how the infant gut can be nourished and supported by providing microbial species, such as Bifidobacterium species, to prevent the growth of potentially pathogenic organisms during this critical window of development. In Chapter 1.1, the importance of these Bifidobacterium is discussed in health and aging and in Chapter 1.2, additional examples of microbial therapeutics is discussed with a view towards early life disorders which have been associated with an altered or disturbed gut microbiome. In Chapter 2, the gut microbial impact of Infloran©, a commercially available probiotic, is examined in a preterm infant cohort to assess the appropriate dosage required for administration in a neonatal care unit. A twice-daily dose of Infloran© was found to significantly increase the relative abundance of bifidobacteria and was subsequently recommended as a suitable dosage for administration in this preterm infant group. In Chapter 3, the identification and characterisation of an infant gut derived, exopolysaccharide producing, Lactobacillus paracasei is discussed. The use of next-generation shotgun sequencing provided information on the genetic capabilities of the microorganism and identified several pathways involved in sugar metabolism. The use of this strain in yoghurt manufacturing was also assessed to identify the industrial potential of the microorganism. In Chapter 4, a novel, narrow-spectrum lantibiotic is discussed as a microbial therapeutic for reducing Group B Streptococcus (GBS) colonisation in pregnant woman and infants. In Chapter 5 this lantibiotic was subsequently compared to a bank of previously identified lantibiotics which exhibited antimicrobial activity against GBS. In Chapter 6, a unique case study examined the effects of therapeutic hypothermia treatment on the gut microbiota composition and metabolome of infants at 2 years of age, who had experienced hypoxic ischemic encephalopathy at birth. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2018, Claire Watkins. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en
dc.subject Gut en
dc.subject Infant en
dc.subject Microbiome en
dc.subject Probiotics en
dc.title Microbial therapeutics for infant gut health en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD en
dc.internal.availability Full text not available en
dc.check.info Not applicable en
dc.description.version Accepted Version
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.contributor.funder University College Cork en
dc.description.status Not peer reviewed en
dc.internal.school Microbiology en
dc.check.type No Embargo Required
dc.check.reason This thesis contains data which has not yet been published en
dc.check.opt-out Yes en
dc.thesis.opt-out true
dc.check.embargoformat Embargo not applicable (If you have not submitted an e-thesis or do not want to request an embargo) en
dc.internal.conferring Summer 2018 en
dc.internal.ricu APC Microbiome Institute en
dc.relation.project University College Cork (APC Microbiome Ireland) en


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© 2018, Claire Watkins. Except where otherwise noted, this item's license is described as © 2018, Claire Watkins.
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