Analysis of the potential for non-invasive imaging of oxygenation at heart depth, using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT)

Show simple item record

dc.contributor.author Walther, Andreas
dc.contributor.author Rippe, Lars
dc.contributor.author Wang, Lihong V.
dc.contributor.author Andersson-Engels, Stefan
dc.contributor.author Kröll, Stefan
dc.date.accessioned 2018-06-15T11:47:18Z
dc.date.available 2018-06-15T11:47:18Z
dc.date.issued 2017
dc.identifier.citation Walther, A., Rippe, L., Wang, L. V., Andersson-Engels, S. and Kröll, S. (2017) 'Analysis of the potential for non-invasive imaging of oxygenation at heart depth, using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT)', Biomedical Optics Express, 8(10), pp. 4523-4536. doi: 10.1364/BOE.8.004523 en
dc.identifier.volume 8
dc.identifier.issued 10
dc.identifier.startpage 4523
dc.identifier.endpage 4536
dc.identifier.issn 2156-7085
dc.identifier.uri http://hdl.handle.net/10468/6352
dc.identifier.doi 10.1364/BOE.8.004523
dc.description.abstract Despite the important medical implications, it is currently an open task to find optical non-invasive techniques that can image deep organs in humans. Addressing this, photo-acoustic tomography (PAT) has received a great deal of attention in the past decade, owing to favorable properties like high contrast and high spatial resolution. However, even with optimal components PAT cannot penetrate beyond a few centimeters, which still presents an important limitation of the technique. Here, we calculate the absorption contrast levels for PAT and for ultrasound optical tomography (UOT) and compare them to their relevant noise sources as a function of imaging depth. The results indicate that a new development in optical filters, based on rare-earth-ion crystals, can push the UOT technique significantly ahead of PAT. Such filters allow the contrastto- noise ratio for UOT to be up to three orders of magnitude better than for PAT at depths of a few cm into the tissue. It also translates into a significant increase of the image depth of UOT compared to PAT, enabling deep organs to be imaged in humans in real time. Furthermore, such spectral holeburning filters are not sensitive to speckle decorrelation from the tissue and can operate at nearly any angle of incident light, allowing good light collection. We theoretically demonstrate the improved performance in the medically important case of non-invasive optical imaging of the oxygenation level of the frontal part of the human myocardial tissue. Our results indicate that further studies on UOT are of interest and that the technique may have large impact on future directions of biomedical optics. (C) 2017 Optical Society of America en
dc.description.sponsorship Fifth Framework Programme (Lund laser centre) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Optical Society of America en
dc.relation.uri https://www.osapublishing.org/boe/abstract.cfm?uri=boe-8-10-4523
dc.rights © 2018, Optical Society of America under the terms of the OSA Open Access Publishing Agreement en
dc.rights.uri https://www.osapublishing.org/library/license_v1.cfm#VOR-OA
dc.subject Biological tissues en
dc.subject Spectroscopy en
dc.subject Modulation en
dc.subject Absorption en
dc.subject Dependence en
dc.subject Frequency en
dc.subject Light en
dc.title Analysis of the potential for non-invasive imaging of oxygenation at heart depth, using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT) en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Stefan Andersson-Engels, Tyndall National Institute, University College Cork, Cork, Ireland +353-21-490-3000 Email: stefan.andersson-engels@tyndall.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Vetenskapsrådet
dc.contributor.funder Fifth Framework Programme
dc.contributor.funder Knut och Alice Wallenbergs Stiftelse
dc.contributor.funder Science Foundation Ireland
dc.description.status Peer reviewed
dc.identifier.journaltitle Biomedical Optics Express en
dc.internal.IRISemailaddress stefan.andersson-engels@tyndall.ie en


Files in this item

This item appears in the following Collection(s)

Show simple item record

This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement