Heterologous expression of biopreservative bacteriocins with a view to low cost production

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dc.contributor.author Mesa-Pereira, Beatriz
dc.contributor.author Rea, Mary C.
dc.contributor.author Cotter, Paul D.
dc.contributor.author Hill, Colin
dc.contributor.author Ross, R. Paul
dc.date.accessioned 2018-08-29T15:47:19Z
dc.date.available 2018-08-29T15:47:19Z
dc.date.issued 2018
dc.identifier.citation Mesa-Pereira, B., Rea, M. C., Cotter, P. D., Hill, C. and Ross, R. P. (2018) 'Heterologous expression of biopreservative bacteriocins with a view to low cost production', Frontiers in Microbiology, 9, 1654 (15pp). doi: 10.3389/fmicb.2018.01654 en
dc.identifier.volume 9
dc.identifier.startpage 1
dc.identifier.endpage 15
dc.identifier.issn 1664-302X
dc.identifier.uri http://hdl.handle.net/10468/6658
dc.identifier.doi 10.3389/fmicb.2018.01654
dc.description.abstract Bacteriocins, a heterogenous group of antibacterial ribosomally synthesized peptides, have potential as bio-preservatives in in a wide range of foods and as future therapeutics for the inhibition of antibiotic-resistant bacteria. While many bacteriocins have been characterized, several factors limit their production in large quantities, a requirement to make them commercially viable for food or pharma applications. The identification of new bacteriocins by database mining has been promising, but their potential is difficult to evaluate in the absence of suitable expression systems. E. coli has been used as a heterologous host to produce recombinant proteins for decades and has an extensive set of expression vectors and strains available. Here, we review the different expression systems for bacteriocin production using this host and identify the most important features to guarantee successful production of a range of bacteriocins. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media en
dc.relation.uri https://www.frontiersin.org/articles/10.3389/fmicb.2018.01654/full
dc.rights © 2018, Mesa-Periera, Rea, Cotter, Hill and Ross. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Bacteriocins en
dc.subject Heterologous expression en
dc.subject Escherichia coli en
dc.subject Vectors en
dc.subject Strains en
dc.title Heterologous expression of biopreservative bacteriocins with a view to low cost production en
dc.type Review en
dc.internal.authorcontactother Paul Ross, College Of Sefs Office, University College Cork, Cork, Ireland. +353-21-490-3000 Email: p.ross@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Microbiology en
dc.internal.IRISemailaddress p.ross@ucc.ie en
dc.identifier.articleid 1654
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/


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© 2018, Mesa-Periera, Rea, Cotter, Hill and Ross. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Except where otherwise noted, this item's license is described as © 2018, Mesa-Periera, Rea, Cotter, Hill and Ross. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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