Implications of standardization of serum 25-hydroxyvitamin D data for the evaluation of vitamin D status in Germany, including a temporal analysis

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dc.contributor.author Rabenberg, Martina
dc.contributor.author Scheidt-Nave, Christa
dc.contributor.author Busch, Markus A.
dc.contributor.author Thamm, Michael
dc.contributor.author Rieckmann, Nina
dc.contributor.author Durazo-Arvizu, Ramón A.
dc.contributor.author Dowling, Kirsten G.
dc.contributor.author Skrabakova, Zuzana
dc.contributor.author Cashman, Kevin D.
dc.contributor.author Sempos, Christopher T.
dc.contributor.author Mensink, Gert B. M.
dc.date.accessioned 2018-08-29T15:47:24Z
dc.date.available 2018-08-29T15:47:24Z
dc.date.issued 2018
dc.identifier.citation Rabenberg, M., Scheidt-Nave, C., Busch, M. A., Thamm, M., Rieckmann, N., Durazo-Arvizu, R. A., Dowling, K. G., Škrabáková, Z., Cashman, K. D., Sempos, C. T. and Mensink, G. B. M. (2018) 'Implications of standardization of serum 25-hydroxyvitamin D data for the evaluation of vitamin D status in Germany, including a temporal analysis', BMC Public Health, 18(1), 845 (14pp). doi: 10.1186/s12889-018-5769-y en
dc.identifier.volume 18
dc.identifier.startpage 1
dc.identifier.endpage 14
dc.identifier.issn 1471-2458
dc.identifier.uri http://hdl.handle.net/10468/6669
dc.identifier.doi 10.1186/s12889-018-5769-y
dc.description.abstract Background: Comparability of 25-hydroxyvitamin D (25(OH)D) measurements is hampered by method-related differences in measurement values. International standardization of laboratory assays has been suggested to solve this problem. Methods: As part of the European Commission-funded project ` Food-based solutions for optimal vitamin D nutrition and health through the life cycle' (ODIN), original measurements of serum 25(OH)D of three German national health surveys conducted between 1998 and 2011 have been standardized retrospectively. In these representative population-based samples including persons aged between 1 and 79 years, the original 25(OH)D values were compared with those after standardization. Mean values and prevalences of vitamin D deficiency, insufficiency, and sufficiency (25(OH)D levels <30, 30-<50, and > =50 nmol/l, respectively) were calculated by sex and age groups based on original and standardized 25(OH)D data. Results: In comparison to the original 25(OH)D levels, the standardized levels showed higher means overall and in age-and sex-specific analyses. After standardization, the prevalence of vitamin D deficiency was lower in all surveys while the prevalence of vitamin D sufficiency was higher. Nevertheless, even after standardization similar to 15% of adults and 12.5% of children had serum 25(OH)D levels <30 nmol/l. Thus, the proportion of deficient vitamin D levels in the German population is still considerable. Conclusions: The use of standardization of 25(OH)D levels has a substantial impact on estimates of the vitamin D status in Germany. Since clinical diagnostic, therapeutic and public health decision-making require valid and comparable data, standardization and calibration of commercial, clinical and research laboratory assays for 25(OH)D measurement should become common practice. Until then, researchers, health practitioners and policy makers should be aware of the peculiarities of the measurement methods when comparing and interpreting 25(OH)D levels. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BioMed Central en
dc.relation.uri https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-018-5769-y
dc.rights © 2018, the Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject Vitamin D en
dc.subject 25(OH)D en
dc.subject Vitamin D deficiency en
dc.subject Standardization en
dc.subject Comparability en
dc.subject Population survey en
dc.subject Germany en
dc.title Implications of standardization of serum 25-hydroxyvitamin D data for the evaluation of vitamin D status in Germany, including a temporal analysis en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Kevin D. Cashman, Food & Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: k.cashman@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Bundesministerium für Ernährung, Landwirtschaft und Verbraucherschutz
dc.contributor.funder Bundesministerium für Bildung und Forschung
dc.contributor.funder Bundesministerium für Gesundheit
dc.description.status Peer reviewed en
dc.identifier.journaltitle BMC Public Health en
dc.internal.IRISemailaddress k.cashman@ucc.ie en
dc.identifier.articleid 845


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© 2018, the Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Except where otherwise noted, this item's license is described as © 2018, the Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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