The genomic basis of Lactobacilli as health-promoting organisms

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dc.contributor.author Salvetti, Elisa
dc.contributor.author O'Toole, Paul W.
dc.date.accessioned 2018-09-24T12:36:59Z
dc.date.available 2018-09-24T12:36:59Z
dc.date.issued 2017
dc.identifier.citation Salvetti, E. and O’Toole, P. W. (2017) 'The genomic basis of Lactobacilli as health-promoting organisms', Microbiology Spectrum, 5(3). pp. 1-17. doi: 10.1128/microbiolspec.BAD-0011-2016 en
dc.identifier.volume 5
dc.identifier.issued 3
dc.identifier.startpage 1
dc.identifier.endpage 17
dc.identifier.uri http://hdl.handle.net/10468/6880
dc.identifier.doi 10.1128/microbiolspec.BAD-0011-2016
dc.description.abstract Lactobacilli occupy a unique position in human culture and scientific history. Like brewer's and baker's yeast, lactobacilli have been associated with food production and preservation for thousands of years. Lactobacillus species are used in mixed microbial cultures, such as the classical Lactobacillus bulgaricus/Streptococcus thermophilus inoculum for yogurt fermentation, or combinations of diverse lactobacilli/yeasts in kefir grains. The association of lactobacilli consumption with greater longevity and improved health formed the basis for developing lactobacilli as probiotics, whose market has exploded worldwide in the past 10 years. The decade that followed the determination of the first genome sequence of a food-associated species, Lactobacillus plantarum, saw the application to lactobacilli of a full range of functional genomics methods to identify the genes and gene products that govern their distinctive phenotypes and health associations. In this review, we will briefly remind the reader of the range of beneficial effects attributed to lactobacilli, and then explain the phylogenomic basis for the distribution of these traits across the genus. Recognizing the strain specificity of probiotic effects, we review studies of intraspecific genomic variation and their contributions to identifying probiotic traits. Finally we offer a perspective on classification of lactobacilli into new genera in a scheme that will make attributing probiotic properties to clades, taxa, and species more logical and more robust. en
dc.description.sponsorship Department of Agriculture, Food and the Marine (FIRM ELDERFOOD and IMMUNOMET) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Society for Microbiology en
dc.relation.uri http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.BAD-0011-2016
dc.rights © 2017, American Society for Microbiology. All rights reserved. en
dc.subject Lactic-acid bacteria en
dc.subject Fermentum cect 5716 en
dc.subject Plantarum wcfs1 en
dc.subject Rhamnosus gg en
dc.subject Gastrointestinal-tract en
dc.subject Competitive-exclusion en
dc.subject Vaginal lactobacilli en
dc.subject Functional-analysis en
dc.subject Immune modulation en
dc.subject Probiotic strain en
dc.title The genomic basis of Lactobacilli as health-promoting organisms en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Paul O'Toole, Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000. Email: pwotoole@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Department of Agriculture, Food and the Marine
dc.contributor.funder Horizon 2020 Framework Programme
dc.contributor.funder Science Foundation Ireland
dc.description.status Peer reviewed en
dc.identifier.journaltitle Microbiology Spectrum en
dc.internal.IRISemailaddress pwotoole@ucc.ie en
dc.identifier.articleid UNSP BAD-0011-2016
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/659801/EU/Consolidating a genomic framework for exploiting lactobacilli/GENOLACT


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