Efficient S-acylation of thiourea

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Efficient S-acylation of thiourea

Jones, David J.; Khandavilli, Udaya Bhaskara Rao; O'Leary, Eileen M.; Lawrence, Simon E.; O'Sullivan, Timothy P.
Date: 2018
Copyright: © 2018 the authors. Published by Thieme Open under Creative Commons License CC BY ND NC 4.0
Copyright information: http://creativecommons.org/licenses/by-nc-nd/4.0/
Related: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0037-1610370
Citation: Jones, D. J., Khandavilli, U. B. R., O’Leary, E. M., Lawrence, S. E. and O’Sullivan, T. P. (2018) 'Efficient S-Acylation of Thiourea', SynOpen, 02(04), pp. 263-267. doi: 10.1055/s-0037-1610370
Published Version: 10.1055/s-0037-1610370

Abstract:

Efficient S-acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology. Confirmation that acylation occurs exclusively­ on the sulfur atom of thiourea is provided by single-crystal X-ray crystallographic analysis.

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© 2018 the authors. Published by Thieme Open under Creative Commons License CC BY ND NC 4.0 Except where otherwise noted, this item's license is described as © 2018 the authors. Published by Thieme Open under Creative Commons License CC BY ND NC 4.0
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