The impact of sarcopenia and myosteatosis on postoperative outcomes in patients with inflammatory bowel disease.

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dc.contributor.author O'Brien, Stephen
dc.contributor.author Kavanagh, Richard G.
dc.contributor.author Carey, Brian W.
dc.contributor.author Maher, Michael M.
dc.contributor.author O'Connor, Owen J.
dc.contributor.author Andrews, Emmet J.
dc.date.accessioned 2018-11-27T14:34:00Z
dc.date.available 2018-11-27T14:34:00Z
dc.date.issued 2018-11-21
dc.identifier.citation O’Brien, S., Kavanagh, R. G., Carey, B. W., Maher, M. M., O’Connor, O. J. and Andrews, E. J. (2018) 'The impact of sarcopenia and myosteatosis on postoperative outcomes in patients with inflammatory bowel disease', European Radiology Experimental, 2(1), 37 (10 pp). doi: 10.1186/s41747-018-0072-3 en
dc.identifier.volume 2 en
dc.identifier.startpage 37-1 en
dc.identifier.endpage 37-10 en
dc.identifier.issn 2509-9280
dc.identifier.uri http://hdl.handle.net/10468/7154
dc.identifier.doi 10.1186/s41747-018-0072-3
dc.description.abstract Background: Inflammatory bowel disease (IBD) is a relatively common disorder with significant associated morbidity. Sarcopenia and myosteatosis are associated with adverse postoperative outcomes. This study investigated outcomes in IBD patients undergoing surgical resection relative to the presence of sarcopenia and myosteatosis. Methods: A retrospective analysis of a prospectively maintained surgical database was conducted. All patients undergoing elective or emergency resection for IBD between 2011 and 2016, with a contemporaneous perioperative computed tomography (CT) scan, were included. Patient demographics, clinical and biochemical measurements were collected. Skeletal muscle index and attenuation were measured on perioperative CT scans using Osirix version 5.6.1. Univariate and multivariate regression analysis was used to identify risk factors for adverse postoperative outcomes. Results: Seventy-seven patients (46 male, 31 female; mean age 42 years, range 20–80 years) were included. Thirty patients (30%) had sarcopenia and 26 (34%) had myosteatosis. Myosteatosis was significantly associated with increased hospital stay postoperatively (9 versus 13 days). Sarcopenia and myosteatosis were associated with hospital readmission within 30 days on univariate analysis. Multivariate regression analysis demonstrated an independent association between myosteatosis and hospital readmission. Sixteen patients (21%) had a clinically relevant postoperative complication, but an association with sarcopenia and myosteatosis was not observed. A neutrophil-lymphocyte ratio greater than 5 was predictive of clinically relevant postoperative complications on multivariate regression analysis. Conclusions: Myosteatosis was associated with increased hospital stay and increased 30-day hospital readmission rates on multivariate regression analysis. Sarcopenia and myosteatosis in IBD were not associated with clinically relevant postoperative complications. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Open en
dc.rights © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Sarcopenia en
dc.subject CT en
dc.subject Myosteatosis en
dc.subject Radiometrics en
dc.subject Inflammatory bowel diseases en
dc.subject Sarcopenia en
dc.subject Muscle (skeletal) en
dc.subject Morbidity en
dc.subject Length of stay en
dc.subject Tomography (x-ray computed) en
dc.title The impact of sarcopenia and myosteatosis on postoperative outcomes in patients with inflammatory bowel disease. en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Owen O'Connor, Medicine , University College Cork, Cork, Ireland. +353-21-490-3000 Email: oj.oconnor@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2018-11-23T14:51:07Z
dc.description.version Published Version en
dc.internal.rssid 462946531
dc.description.status Peer reviewed en
dc.identifier.journaltitle European Radiology Experimental en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress oj.oconnor@ucc.ie en


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© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Except where otherwise noted, this item's license is described as © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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